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Weak Higher-Order Interactions in Macroscopic Functional Networks of the Resting Brain
Huang, Xuhui1,2,3,4; Xu, Kaibin1,2,4,5; Chu, Congying1,2,4,5; Jiang, Tianzi1,2,4,6; Yu, Shan1,2,4,5
2017-10-25
发表期刊JOURNAL OF NEUROSCIENCE
卷号37期号:43页码:10481-10497
文章类型Article
摘要Interactions among different brain regions are usually examined through functional connectivity (FC) analysis, which is exclusively based on measuring pairwise correlations in activities. However, interactions beyond the pairwise level, that is, higher-order interactions (HOIs), are vital in understanding the behavior of many complex systems. So far, whether HOIs exist among brain regions and how they can affect the brain's activities remains largely elusive. To address these issues, here, we analyzed blood oxygenation level-dependent (BOLD) signals recorded from six typical macroscopic functional networks of the brain in 100 human subjects (46 males and 54 females) during the resting state. Through examining the binarized BOLD signals, we found that HOIs within and across individual networks were both very weak regardless of the network size, topology, degree of spatial proximity, spatial scales, and whether the global signal was regressed. To investigate the potential mechanisms underlying the weak HOIs, we analyzed the dynamics of a network model and also found that HOIs were generally weak within a wide range of key parameters provided that the overall dynamic feature of the model was similar to the empirical data and it was operating close to a linear fluctuation regime. Our results suggest that weak HOI may be a general property of brain's macroscopic functional networks, which implies the dominance of pairwise interactions in shaping brain activities at such a scale and warrants the validity of widely used pairwise-based FC approaches.
关键词Default Mode Network Frontoparietal Network Functional Connectivity Pairwise Correlation Resting-state Fmri
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1523/JNEUROSCI.0451-17.2017
关键词[WOS]INFORMATION-GEOMETRIC MEASURE ; ALZHEIMERS-DISEASE ; CORTICAL NETWORKS ; DEFAULT-MODE ; NEURONAL AVALANCHES ; NEURAL POPULATION ; CONNECTIVITY MRI ; MOTION ARTIFACT ; GLOBAL SIGNAL ; AWAKE MONKEYS
收录类别SCI
语种英语
项目资助者National Key Research and Development Program of China(2017YFA0105203) ; Natural Science Foundation of China(81471368 ; Chinese Academy of Sciences (CAS)(XDB02060003 ; China Postdoctoral Science Foundation(2015T80154) ; CAS ; CAS(QYZDJ-SSW-SMC019) ; Beijing Municipal Science and Technology Commission(Z161100000216139) ; 11505283 ; XDB02030300) ; 91132301 ; 91432302)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000413745200018
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15483
专题类脑智能研究中心
通讯作者Yu, Shan
作者单位1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Univ Elect Sci & Technol China, MOE Key Lab Neuroinformat, Chengdu Brain Sci Inst, Clin Hosp, Chengdu 625014, Sichuan, Peoples R China
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Huang, Xuhui,Xu, Kaibin,Chu, Congying,et al. Weak Higher-Order Interactions in Macroscopic Functional Networks of the Resting Brain[J]. JOURNAL OF NEUROSCIENCE,2017,37(43):10481-10497.
APA Huang, Xuhui,Xu, Kaibin,Chu, Congying,Jiang, Tianzi,&Yu, Shan.(2017).Weak Higher-Order Interactions in Macroscopic Functional Networks of the Resting Brain.JOURNAL OF NEUROSCIENCE,37(43),10481-10497.
MLA Huang, Xuhui,et al."Weak Higher-Order Interactions in Macroscopic Functional Networks of the Resting Brain".JOURNAL OF NEUROSCIENCE 37.43(2017):10481-10497.
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