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Weak Higher-Order Interactions in Macroscopic Functional Networks of the Resting Brain
Huang, Xuhui1,2,3,4; Xu, Kaibin1,2,4,5; Chu, Congying1,2,4,5; Jiang, Tianzi1,2,4,6; Yu, Shan1,2,4,5
Source PublicationJOURNAL OF NEUROSCIENCE
2017-10-25
Volume37Issue:43Pages:10481-10497
SubtypeArticle
AbstractInteractions among different brain regions are usually examined through functional connectivity (FC) analysis, which is exclusively based on measuring pairwise correlations in activities. However, interactions beyond the pairwise level, that is, higher-order interactions (HOIs), are vital in understanding the behavior of many complex systems. So far, whether HOIs exist among brain regions and how they can affect the brain's activities remains largely elusive. To address these issues, here, we analyzed blood oxygenation level-dependent (BOLD) signals recorded from six typical macroscopic functional networks of the brain in 100 human subjects (46 males and 54 females) during the resting state. Through examining the binarized BOLD signals, we found that HOIs within and across individual networks were both very weak regardless of the network size, topology, degree of spatial proximity, spatial scales, and whether the global signal was regressed. To investigate the potential mechanisms underlying the weak HOIs, we analyzed the dynamics of a network model and also found that HOIs were generally weak within a wide range of key parameters provided that the overall dynamic feature of the model was similar to the empirical data and it was operating close to a linear fluctuation regime. Our results suggest that weak HOI may be a general property of brain's macroscopic functional networks, which implies the dominance of pairwise interactions in shaping brain activities at such a scale and warrants the validity of widely used pairwise-based FC approaches.
KeywordDefault Mode Network Frontoparietal Network Functional Connectivity Pairwise Correlation Resting-state Fmri
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1523/JNEUROSCI.0451-17.2017
WOS KeywordINFORMATION-GEOMETRIC MEASURE ; ALZHEIMERS-DISEASE ; CORTICAL NETWORKS ; DEFAULT-MODE ; NEURONAL AVALANCHES ; NEURAL POPULATION ; CONNECTIVITY MRI ; MOTION ARTIFACT ; GLOBAL SIGNAL ; AWAKE MONKEYS
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China(2017YFA0105203) ; Natural Science Foundation of China(81471368 ; Chinese Academy of Sciences (CAS)(XDB02060003 ; China Postdoctoral Science Foundation(2015T80154) ; CAS ; CAS(QYZDJ-SSW-SMC019) ; Beijing Municipal Science and Technology Commission(Z161100000216139) ; 11505283 ; XDB02030300) ; 91132301 ; 91432302)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000413745200018
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15483
Collection类脑智能研究中心
Corresponding AuthorYu, Shan
Affiliation1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Univ Elect Sci & Technol China, MOE Key Lab Neuroinformat, Chengdu Brain Sci Inst, Clin Hosp, Chengdu 625014, Sichuan, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China;  Institute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
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GB/T 7714
Huang, Xuhui,Xu, Kaibin,Chu, Congying,et al. Weak Higher-Order Interactions in Macroscopic Functional Networks of the Resting Brain[J]. JOURNAL OF NEUROSCIENCE,2017,37(43):10481-10497.
APA Huang, Xuhui,Xu, Kaibin,Chu, Congying,Jiang, Tianzi,&Yu, Shan.(2017).Weak Higher-Order Interactions in Macroscopic Functional Networks of the Resting Brain.JOURNAL OF NEUROSCIENCE,37(43),10481-10497.
MLA Huang, Xuhui,et al."Weak Higher-Order Interactions in Macroscopic Functional Networks of the Resting Brain".JOURNAL OF NEUROSCIENCE 37.43(2017):10481-10497.
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