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Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study
Zhang, Yujin1,2; Yang, Yi3; Si, Juanning1,2; Xia, Xiaoyu3; He, Jianghong3; Jiang, Tianzi1,2,4,5,6
2018
发表期刊NEUROIMAGE-CLINICAL
卷号17期号:2018页码:1-9
文章类型Article
摘要Spinal cord stimulation (SCS) is a promising treatment for disorders of consciousness (DOC), but the underlying mechanism and most effective procedures remain uncertain. To optimize the protocol, previous studies evaluated the frequency-specific effects of SCS on neurophysiological activities. However, whether and how the inter-stimulus interval (ISI) parameter affects the SCS neuromodulation in DOC remains unknown. We enrolled nine DOC patients who had implanted SCS devices and conducted three different durations of ISIs. Using functional near-infrared spectroscopy (fNIRS), we monitored the blood volume fluctuations in the prefrontal and occipital cortices during the SCS. The results showed that short stimuli (30 s) induced significant cerebral blood volume changes, especially in the prefrontal cortex, an important area in the consciousness system. By comparing the mean value of the responses from the first and the last block in each session, a shorter ISI was found to improve the blood volume in the prefrontal cortex. This phenomenon was more significant for the subgroup of patients with a favorable prognosis. These preliminary results imply that the ISI may be an important factor for SCS. The research paradigm proposed here also provides insights for further quantitative evaluations of the therapeutic effects of neuromodulation.
关键词Disorders Of Consciousness Spinal Cord Stimulation Functional Near-infrared Spectroscopy Inter-stimulus Interval Prefrontal Cortex
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nicl.2017.09.017
关键词[WOS]PERSISTENT VEGETATIVE STATE ; BRAIN-INJURY ; THERAPEUTIC INTERVENTIONS ; CEREBRAL METABOLISM ; BLOOD-VOLUME ; CORTEX ; CONNECTIVITY ; MEMORY ; TIME ; COMA
收录类别SCI ; SSCI
语种英语
项目资助者National Key Research and Development Program of China(2017YFB1002502) ; National Natural Science Foundation of China(31571003 ; National Natural Science Foundation of Beijing(7164302) ; 81501550 ; 81600919)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000426180300001
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15488
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.PLA Army Gen Hosp, Dept Neurosurg, Beijing 100700, Peoples R China
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 625014, Sichuan, Peoples R China
5.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing 100190, Peoples R China
6.Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia
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Zhang, Yujin,Yang, Yi,Si, Juanning,et al. Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study[J]. NEUROIMAGE-CLINICAL,2018,17(2018):1-9.
APA Zhang, Yujin,Yang, Yi,Si, Juanning,Xia, Xiaoyu,He, Jianghong,&Jiang, Tianzi.(2018).Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study.NEUROIMAGE-CLINICAL,17(2018),1-9.
MLA Zhang, Yujin,et al."Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study".NEUROIMAGE-CLINICAL 17.2018(2018):1-9.
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