CASIA OpenIR  > 脑网络组研究中心
Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study
Zhang, Yujin1,2; Yang, Yi3; Si, Juanning1,2; Xia, Xiaoyu3; He, Jianghong3; Jiang, Tianzi1,2,4,5,6
Source PublicationNEUROIMAGE-CLINICAL
2018
Volume17Issue:2018Pages:1-9
SubtypeArticle
AbstractSpinal cord stimulation (SCS) is a promising treatment for disorders of consciousness (DOC), but the underlying mechanism and most effective procedures remain uncertain. To optimize the protocol, previous studies evaluated the frequency-specific effects of SCS on neurophysiological activities. However, whether and how the inter-stimulus interval (ISI) parameter affects the SCS neuromodulation in DOC remains unknown. We enrolled nine DOC patients who had implanted SCS devices and conducted three different durations of ISIs. Using functional near-infrared spectroscopy (fNIRS), we monitored the blood volume fluctuations in the prefrontal and occipital cortices during the SCS. The results showed that short stimuli (30 s) induced significant cerebral blood volume changes, especially in the prefrontal cortex, an important area in the consciousness system. By comparing the mean value of the responses from the first and the last block in each session, a shorter ISI was found to improve the blood volume in the prefrontal cortex. This phenomenon was more significant for the subgroup of patients with a favorable prognosis. These preliminary results imply that the ISI may be an important factor for SCS. The research paradigm proposed here also provides insights for further quantitative evaluations of the therapeutic effects of neuromodulation.
KeywordDisorders Of Consciousness Spinal Cord Stimulation Functional Near-infrared Spectroscopy Inter-stimulus Interval Prefrontal Cortex
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nicl.2017.09.017
WOS KeywordPERSISTENT VEGETATIVE STATE ; BRAIN-INJURY ; THERAPEUTIC INTERVENTIONS ; CEREBRAL METABOLISM ; BLOOD-VOLUME ; CORTEX ; CONNECTIVITY ; MEMORY ; TIME ; COMA
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Key Research and Development Program of China(2017YFB1002502) ; National Natural Science Foundation of China(31571003 ; National Natural Science Foundation of Beijing(7164302) ; 81501550 ; 81600919)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000426180300001
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15488
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.PLA Army Gen Hosp, Dept Neurosurg, Beijing 100700, Peoples R China
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 625014, Sichuan, Peoples R China
5.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing 100190, Peoples R China
6.Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yujin,Yang, Yi,Si, Juanning,et al. Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study[J]. NEUROIMAGE-CLINICAL,2018,17(2018):1-9.
APA Zhang, Yujin,Yang, Yi,Si, Juanning,Xia, Xiaoyu,He, Jianghong,&Jiang, Tianzi.(2018).Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study.NEUROIMAGE-CLINICAL,17(2018),1-9.
MLA Zhang, Yujin,et al."Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study".NEUROIMAGE-CLINICAL 17.2018(2018):1-9.
Files in This Item: Download All
File Name/Size DocType Version Access License
Zhang2017-NeuroImage(1156KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Yujin]'s Articles
[Yang, Yi]'s Articles
[Si, Juanning]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Yujin]'s Articles
[Yang, Yi]'s Articles
[Si, Juanning]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Yujin]'s Articles
[Yang, Yi]'s Articles
[Si, Juanning]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Zhang2017-NeuroImageClinical.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.