CASIA OpenIR  > 中国科学院分子影像重点实验室
High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy
Wei, Qiaolin1,2; Chen, Yao1; Ma, Xibo3; Ji, Jianfeng1; Qiao, Yue1,2; Zhou, Bo1,2; Ma, Fei2; Ling, Daishun4; Zhang, Hong1; Tian, Mei1; Tian, Jie3; Zhou, Min1,2,5,6
Source PublicationADVANCED FUNCTIONAL MATERIALS
2018-01-10
Volume28Issue:2Pages:1704634
SubtypeArticle
AbstractRenal-clearable nanoparticles have made it possible to overcome the toxicity by nonspecific accumulation in healthy tissues/ organs due to their highly efficient clearance characteristics. However, their tumor uptake is relatively low due to the short blood circulation time and rapid body elimination. Here, this problem is addressed by developing renal-clearable nanoparticles by controlled coating of sub-6 nm CuS nanodots (CuSNDs) on doxorubicin ladened mesoporous silica nanoparticles (pore size approximate to 6 nm) for multimodal application. High tumor uptake of the as-synthesized nanoparticles (abbreviated as MDNs) is achieved due to the longer blood circulation time. The MDNs also show excellent performance in bimodal imaging. Moreover, the MDNs demonstrated a photothermally sensitive drug release and pronounced synergetic effects of chemo-photothermal therapy, which were confirmed by two different tumor models in vivo. A novel key feature of the proposed synthesis is the use of renal-clearable CuSNDs and biodegradable mesoporous silica nanoparticles which also are renal-clearable after degradation. Therefore, the MDNs would be rapidly degraded and excreted in a reasonable period in living body and avoid long-term toxicity. Such biodegradable and clearable single-compartment theranostic agents applicable in highly integrated multimodal imaging and multiple therapeutic functions may have substantial potentials in clinical practice.
KeywordBiodegradation Multimodal Imaging Nanoplatforms Renal Clearance Theranostics
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201704634
WOS KeywordMESOPOROUS SILICA NANOPARTICLES ; CONTRAST AGENTS ; RENAL CLEARANCE ; DRUG-DELIVERY ; QUANTUM DOTS ; BIODISTRIBUTION ; TISSUE
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China(2016YFA0100900) ; National Key Basic Research Program of the China(2014CB744504) ; National Natural Science Foundation of China(81671748) ; Project of Chinese Thousand Youth Talents
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000419454000013
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/19555
Collection中国科学院分子影像重点实验室
Affiliation1.Zhejiang Univ, Affiliated Hosp 2, Sch Med, PET Ctr,Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China
2.Zhejiang Univ, Inst Translat Med, Hangzhou 310009, Zhejiang, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310009, Zhejiang, Peoples R China
5.Zhejiang Univ, Minist Educ, Key Lab Early Warning & Intervent Malignant Tumor, Hangzhou 310009, Zhejiang, Peoples R China
6.Zhejiang Univ, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Wei, Qiaolin,Chen, Yao,Ma, Xibo,et al. High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(2):1704634.
APA Wei, Qiaolin.,Chen, Yao.,Ma, Xibo.,Ji, Jianfeng.,Qiao, Yue.,...&Zhou, Min.(2018).High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,28(2),1704634.
MLA Wei, Qiaolin,et al."High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS 28.2(2018):1704634.
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