Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy | |
Wei, Qiaolin1,2; Chen, Yao1; Ma, Xibo3; Ji, Jianfeng1; Qiao, Yue1,2; Zhou, Bo1,2; Ma, Fei2; Ling, Daishun4; Zhang, Hong1; Tian, Mei1; Tian, Jie3; Zhou, Min1,2,5,6 | |
发表期刊 | ADVANCED FUNCTIONAL MATERIALS |
2018-01-10 | |
卷号 | 28期号:2页码:1704634 |
文章类型 | Article |
摘要 | Renal-clearable nanoparticles have made it possible to overcome the toxicity by nonspecific accumulation in healthy tissues/ organs due to their highly efficient clearance characteristics. However, their tumor uptake is relatively low due to the short blood circulation time and rapid body elimination. Here, this problem is addressed by developing renal-clearable nanoparticles by controlled coating of sub-6 nm CuS nanodots (CuSNDs) on doxorubicin ladened mesoporous silica nanoparticles (pore size approximate to 6 nm) for multimodal application. High tumor uptake of the as-synthesized nanoparticles (abbreviated as MDNs) is achieved due to the longer blood circulation time. The MDNs also show excellent performance in bimodal imaging. Moreover, the MDNs demonstrated a photothermally sensitive drug release and pronounced synergetic effects of chemo-photothermal therapy, which were confirmed by two different tumor models in vivo. A novel key feature of the proposed synthesis is the use of renal-clearable CuSNDs and biodegradable mesoporous silica nanoparticles which also are renal-clearable after degradation. Therefore, the MDNs would be rapidly degraded and excreted in a reasonable period in living body and avoid long-term toxicity. Such biodegradable and clearable single-compartment theranostic agents applicable in highly integrated multimodal imaging and multiple therapeutic functions may have substantial potentials in clinical practice. |
关键词 | Biodegradation Multimodal Imaging Nanoplatforms Renal Clearance Theranostics |
WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
DOI | 10.1002/adfm.201704634 |
关键词[WOS] | MESOPOROUS SILICA NANOPARTICLES ; CONTRAST AGENTS ; RENAL CLEARANCE ; DRUG-DELIVERY ; QUANTUM DOTS ; BIODISTRIBUTION ; TISSUE |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National Key Research and Development Program of China(2016YFA0100900) ; National Key Basic Research Program of the China(2014CB744504) ; National Natural Science Foundation of China(81671748) ; Project of Chinese Thousand Youth Talents |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
WOS记录号 | WOS:000419454000013 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/19555 |
专题 | 中国科学院分子影像重点实验室 |
作者单位 | 1.Zhejiang Univ, Affiliated Hosp 2, Sch Med, PET Ctr,Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China 2.Zhejiang Univ, Inst Translat Med, Hangzhou 310009, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310009, Zhejiang, Peoples R China 5.Zhejiang Univ, Minist Educ, Key Lab Early Warning & Intervent Malignant Tumor, Hangzhou 310009, Zhejiang, Peoples R China 6.Zhejiang Univ, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Wei, Qiaolin,Chen, Yao,Ma, Xibo,et al. High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(2):1704634. |
APA | Wei, Qiaolin.,Chen, Yao.,Ma, Xibo.,Ji, Jianfeng.,Qiao, Yue.,...&Zhou, Min.(2018).High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,28(2),1704634. |
MLA | Wei, Qiaolin,et al."High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS 28.2(2018):1704634. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
10.1002@adfm.2017046(6497KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论