CASIA OpenIR  > 中国科学院分子影像重点实验室
Bioluminescence Tomography Based on Gaussian Weighted Laplace Prior Regularization for In Vivo Morphological Imaging of Glioma
Gao, Yuan1,4; Wang, Kun1; Jiang, Shixin2; Liu, Yuhao2; Ai, Ting3; Tian, Jie1,4
发表期刊IEEE TRANSACTIONS ON MEDICAL IMAGING
2017-11-01
卷号36期号:11页码:2343-2354
文章类型Article
摘要

Bioluminescence tomography (BLT) is a powerful non-invasive molecular imaging tool for in vivo studies of glioma in mice. However, because of the light scattering and resulted ill-posed problems, it is challenging to develop a sufficient reconstruction method, which can accurately locate the tumor and define the tumor morphology in three-dimension. In this paper, we proposed a novel Gaussian weighted Laplace prior (GWLP) regularization method. It considered the variance of the bioluminescence energy between any two voxels inside an organ had a non-linear inverse relationship with their Gaussian distance to solve the over-smoothed tumor morphology in BLT reconstruction. We compared the GWLP with conventional Tikhonov and Laplace regularization methods through various numerical simulations and in vivo orthotopic glioma mouse model experiments. The in vivo magnetic resonance imaging and ex vivo green fluorescent protein images and hematoxylin-eosin stained images of whole head cryoslicing specimens were utilized as gold standards. The results demonstrated that GWLP achieved the highest accuracy in tumor localization and tumor morphology preservation. To the best of our knowledge, this is the first study that achieved such accurate BLT morphological reconstruction of orthotopic glioma without using any segmented tumor structure from any other structural imaging modalities as the prior for reconstruction guidance. This enabled BLT more suitable and practical for in vivo imaging of orthotopic glioma mouse models.

关键词Bioluminescence Tomography Multimodality Fusion Brain
WOS标题词Science & Technology ; Technology ; Life Sciences & Biomedicine
DOI10.1109/TMI.2017.2737661
关键词[WOS]FLUORESCENCE MOLECULAR TOMOGRAPHY ; RECONSTRUCTION METHOD ; OPTICAL TOMOGRAPHY ; LIGHT ; INFORMATION ; ALGORITHM ; MRI ; OPTIMIZATION ; SYSTEM ; REGION
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2015CB755500) ; National Natural Science Foundation of China(81227901 ; CAS Youth Innovation Promotion Association(Y6S7021X51) ; 61671449 ; 81527805 ; 61231004 ; 61401462)
WOS研究方向Computer Science ; Engineering ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Computer Science, Interdisciplinary Applications ; Engineering, Biomedical ; Engineering, Electrical & Electronic ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000414134200014
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/19557
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Beijing 100044, Peoples R China
3.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
4.University of Chinese Academy of Sciences, Beijing 100049, Peoples R China
第一作者单位中国科学院分子影像重点实验室
推荐引用方式
GB/T 7714
Gao, Yuan,Wang, Kun,Jiang, Shixin,et al. Bioluminescence Tomography Based on Gaussian Weighted Laplace Prior Regularization for In Vivo Morphological Imaging of Glioma[J]. IEEE TRANSACTIONS ON MEDICAL IMAGING,2017,36(11):2343-2354.
APA Gao, Yuan,Wang, Kun,Jiang, Shixin,Liu, Yuhao,Ai, Ting,&Tian, Jie.(2017).Bioluminescence Tomography Based on Gaussian Weighted Laplace Prior Regularization for In Vivo Morphological Imaging of Glioma.IEEE TRANSACTIONS ON MEDICAL IMAGING,36(11),2343-2354.
MLA Gao, Yuan,et al."Bioluminescence Tomography Based on Gaussian Weighted Laplace Prior Regularization for In Vivo Morphological Imaging of Glioma".IEEE TRANSACTIONS ON MEDICAL IMAGING 36.11(2017):2343-2354.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Bioluminescence Tomo(1962KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
TMI_corrections.pdf(348KB)其他 开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Gao, Yuan]的文章
[Wang, Kun]的文章
[Jiang, Shixin]的文章
百度学术
百度学术中相似的文章
[Gao, Yuan]的文章
[Wang, Kun]的文章
[Jiang, Shixin]的文章
必应学术
必应学术中相似的文章
[Gao, Yuan]的文章
[Wang, Kun]的文章
[Jiang, Shixin]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Bioluminescence Tomography Based on.pdf
格式: Adobe PDF
此文件暂不支持浏览
文件名: TMI_corrections.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。