Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method

doi:10.1007/s11307-016-0970-9

	Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method
	Yifang Hu1,2 ; Jie Liu1,5 ; Chengcai Leng 2,3; Yu An 1; Shuang Zhang 4; Kun Wang2
发表期刊	Molecular Imaging and Biology
	2016
期号	18 页码:830-837
摘要	Purpose: Bioluminescence tomography (BLT) is a promising in vivo optical imaging technique in preclinical research at cellular and molecular levels. The problem of BLT reconstruction is quite ill-posed and ill-conditioned. In order to achieve high accuracy and efficiency for its inverse reconstruction, we proposed a novel approach based on Lp regularization with the Split Bregman method. Procedures: The diffusion equation was used as the forward model. Then, we defined the objective function of Lp regularization and developed a Split Bregman iteration algorithm to optimize this function. After that, we conducted numerical simulations and in vivo experiments to evaluate the accuracy and efficiency of the proposed method. Results: The results of the simulations indicated that compared with the conjugate gradient and iterative shrinkage methods, the proposed method is more accurate and faster for multisource reconstructions. Furthermore ,in vivo imaging suggested that it could clearly distinguish the viable and apoptotic tumor regions. Conclusions: The Split Bregman iteration method is able to minimize the Lp regularization problem and achieve fast and accurate reconstruction in BLT.
关键词	Bioluminescence Tomography (Blt) Lp Regularization Image Reconstruction Split Bregman Method
DOI	10.1007/s11307-016-0970-9
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/19560
专题	中国科学院分子影像重点实验室
作者单位	1.School of Computer and Information Technology, Beijing Jiaotong University, Beijing, 100044, China 2.Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Zhongguancun East Road #95, Haidian Dist., Beijing, 100190, People’s Republic of China 3.School of Mathematics and Information Sciences, Nanchang Hangkong University, Nanchang, 330063, China 4.Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, 110819, China 5.Department of Biomedical Engineering, Beijing Jiaotong University, School of Computer and Information, Shangyuancun 3#, Beijing, 100044, People’s Republic of China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Yifang Hu,Jie Liu,Chengcai Leng,et al. Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method[J]. Molecular Imaging and Biology,2016(18):830-837.
APA	Yifang Hu,Jie Liu,Chengcai Leng,Yu An,Shuang Zhang,&Kun Wang.(2016).Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method.Molecular Imaging and Biology(18),830-837.
MLA	Yifang Hu,et al."Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method".Molecular Imaging and Biology .18(2016):830-837.

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