CASIA OpenIR  > 中国科学院分子影像重点实验室
Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method
Yifang Hu1,2; Jie Liu1,5; Chengcai Leng2,3; Yu An1; Shuang Zhang4; Kun Wang2
Source PublicationMolecular Imaging and Biology
AbstractPurpose: Bioluminescence tomography (BLT) is a promising in vivo optical imaging technique in
preclinical research at cellular and molecular levels. The problem of BLT reconstruction is quite
ill-posed and ill-conditioned. In order to achieve high accuracy and efficiency for its inverse
reconstruction, we proposed a novel approach based on 
Lp regularization with the Split
Bregman method.

Procedures: The diffusion equation was used as the forward model. Then, we defined the
objective function of 
Lp regularization and developed a Split Bregman iteration algorithm to
optimize this function. After that, we conducted numerical simulations and 
in vivo experiments to
evaluate the accuracy and efficiency of the proposed method.

Results: The results of the simulations indicated that compared with the conjugate gradient and
iterative shrinkage methods, the proposed method is more accurate and faster for multisource
reconstructions. Furthermore ,
in vivo imaging suggested that it could clearly distinguish the
viable and apoptotic tumor regions.

Conclusions: The Split Bregman iteration method is able to minimize the Lp regularization
problem and achieve fast and accurate reconstruction in BLT.

KeywordBioluminescence Tomography (Blt) Lp Regularization Image Reconstruction Split Bregman Method
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.School of Computer and Information Technology, Beijing Jiaotong University, Beijing, 100044, China
2.Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Zhongguancun East Road #95, Haidian Dist., Beijing, 100190, People’s Republic of China
3.School of Mathematics and Information Sciences, Nanchang Hangkong University, Nanchang, 330063, China
4.Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, 110819, China
5.Department of Biomedical Engineering, Beijing Jiaotong University, School of Computer and Information, Shangyuancun 3#, Beijing, 100044, People’s Republic of China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yifang Hu,Jie Liu,Chengcai Leng,et al. Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method[J]. Molecular Imaging and Biology,2016(18):830-837.
APA Yifang Hu,Jie Liu,Chengcai Leng,Yu An,Shuang Zhang,&Kun Wang.(2016).Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method.Molecular Imaging and Biology(18),830-837.
MLA Yifang Hu,et al."Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method".Molecular Imaging and Biology .18(2016):830-837.
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