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Ultrasound Imaging Based on Molecular Targeting for Quantitative Evaluation of Hepatic Ischemia-Reperfusion Injury
Chen Qiu; Tinghui Yina; Yingcai Zhang; Yufan Lian; Yujia You; Kun Wang; Rongqin Zheng; Xintao Shuai
Source PublicationAmerican Journal of Transplantation
2017
Volume17Issue:12Pages:3087–3097
AbstractThe present study aimed to quantitatively diagnose and monitor the therapy response of hepatic ischemia reperfusion injury (IRI) with targeted ultrasound (US) imaging. Targeted microbubbles (MBs) were fabricated, and the binding of ICAM-1 antibodies to MBs was observed. To establish a quantitative method based on targeted US imaging, contrast-enhanced ultrasound (CEUS) was applied on IRI rats. After andrographolide treatment, the IRI rats were subjected to the quantitative targeted US imaging for a therapeutic effect. Effective binding of ICAM-1 antibodies to MBs was observed. According to the quantitative targeted US imaging, the ICAM-1 normalized intensity difference (NID) in IRI rats (38.74 ± 15.08%) was significantly higher than that in the control rats (10.08 ± 2.52%, P = 0.048). Furthermore, different degrees of IRI (mild IRI, moderate to severe IRI) were distinguished by the use of NID (37.14 ± 2.14, 22.34 ± 1.08, P = 0.002). Analysis of mRNA expression demonstrated the accuracy of analyzing the NID using quantitative targeted US imaging (R2 = 0.7434, P < 0.001). Andrographolide treatment resulted in obviously weakened NID of ICAM-1 (17.7 ± 4.8% vs 34.2 ± 6.6%, P < 0.001). The study showed the potential of the quantitative targeted US imaging method for the diagnosis and therapeutic monitoring of IRI.
KeywordUltrasound Imaging Hepatic Ischemia Reperfusion Injury Molecular Targeting
DOI10.1111/ajt.14345
WOS IDWOS:000418567000014
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/19562
Collection中国科学院分子影像重点实验室
Affiliation1.Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
2.Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
3.Department of Liver Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
4.Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Science, Beijing 100190, China
5.PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
6.Center for Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510275, China.
Recommended Citation
GB/T 7714
Chen Qiu,Tinghui Yina,Yingcai Zhang,et al. Ultrasound Imaging Based on Molecular Targeting for Quantitative Evaluation of Hepatic Ischemia-Reperfusion Injury[J]. American Journal of Transplantation,2017,17(12):3087–3097.
APA Chen Qiu.,Tinghui Yina.,Yingcai Zhang.,Yufan Lian.,Yujia You.,...&Xintao Shuai.(2017).Ultrasound Imaging Based on Molecular Targeting for Quantitative Evaluation of Hepatic Ischemia-Reperfusion Injury.American Journal of Transplantation,17(12),3087–3097.
MLA Chen Qiu,et al."Ultrasound Imaging Based on Molecular Targeting for Quantitative Evaluation of Hepatic Ischemia-Reperfusion Injury".American Journal of Transplantation 17.12(2017):3087–3097.
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