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Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model
Du, Yang1,2; Sun, Ting3; Liang, Xiaolong4; Li, Yuan3; Jin, Zhengyu3; Xue, Huadan3; Wan, Yihong5; Tian, Jie1,2
2017
发表期刊INTERNATIONAL JOURNAL OF NANOMEDICINE
卷号12期号:12页码:8337-8351
文章类型Article
摘要An intraoperative technique to accurately identify microscopic tumor residuals could decrease the risk of positive surgical margins. Several lines of evidence support the expression and immunotherapeutie effect of PD-1 in breast cancer. Here, we sought to develop a fluorescence-labeled PD-1 probe for in vivo breast tumor imaging and image-guided surgery. The efficacy of PD-1 monoclonal antibody (PD-1 mAb) as adjuvant immunotherapy after surgery was also assessed. PD-1-I RDyc800CW was developed and examined for its application in tumor imaging and image-guided tumor resection in an immunocompetent 4T1 mouse tumor model. Fluorescence molecular imaging was performed to monitor probe biodistribution and intraoperative imaging. Bioluminescence imaging was performed to monitor tumor growth and evaluate postsurgical tumor residuals, recurrences, and metastases. The PD-1-IRDye800CW exhibited a specific signal at the tumor region compared with the IgG control. Furthermore, PD-1-IRDye800CW-guided surgery combined with PD-1 adjuvant immunotherapy inhibited tumor rcgrowth and microtumor metastases and thus improved survival rate. Our study demonstrates the feasibility of using PD-1-IRDye800CW for breast tumor imaging and image-guided tumor resection. Moreover, PD-1 mAb adjuvant immunotherapy reduces cancer recurrences and metastases emanating from tumor residuals.
关键词Pd-1 Programmed Cell Death-1 Near-infrared Fluorescence (Nirf) Breast Cancer Image-guided Surgery Immunotherapy Fluorescence Imaging
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.2147/IJN.S149235
关键词[WOS]CANCER-IMMUNOTHERAPY ; BREAST-CANCER ; ANTI-PD-L1 ANTIBODY ; ADVANCED MELANOMA ; SAFETY ; RESPONSES ; EXPRESSION ; BLOCKADE ; LYMPHOCYTES ; NIVOLUMAB
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81227901 ; Research and Development Program of China (973)(2014CB748600 ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; Beijing Natural Science Foundation(Z16110200010000) ; Peking University Third Hospital(BYSY2015023) ; China Postdoctoral Science Foundation(2013M530014) ; Cancer Prevention Research Institute of Texas(RP130145) ; US Department of Defense(W81XWH-13-1-0318) ; Welch Foundation(1-1751) ; Mary Kay Foundation(073.14) ; 81470083 ; 2015CB755500) ; 81527805 ; 81571810 ; 61231004 ; 81771846 ; 81201186)
WOS研究方向Science & Technology - Other Topics ; Pharmacology & Pharmacy
WOS类目Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS记录号WOS:000415814100002
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/19584
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Radiol, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Dept Ultrasound, Beijing, Peoples R China
5.Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
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Du, Yang,Sun, Ting,Liang, Xiaolong,et al. Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12(12):8337-8351.
APA Du, Yang.,Sun, Ting.,Liang, Xiaolong.,Li, Yuan.,Jin, Zhengyu.,...&Tian, Jie.(2017).Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model.INTERNATIONAL JOURNAL OF NANOMEDICINE,12(12),8337-8351.
MLA Du, Yang,et al."Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model".INTERNATIONAL JOURNAL OF NANOMEDICINE 12.12(2017):8337-8351.
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