CASIA OpenIR  > 中国科学院分子影像重点实验室
Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model
Du, Yang1,2; Sun, Ting3; Liang, Xiaolong4; Li, Yuan3; Jin, Zhengyu3; Xue, Huadan3; Wan, Yihong5; Tian, Jie1,2
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
2017
Volume12Issue:12Pages:8337-8351
SubtypeArticle
AbstractAn intraoperative technique to accurately identify microscopic tumor residuals could decrease the risk of positive surgical margins. Several lines of evidence support the expression and immunotherapeutie effect of PD-1 in breast cancer. Here, we sought to develop a fluorescence-labeled PD-1 probe for in vivo breast tumor imaging and image-guided surgery. The efficacy of PD-1 monoclonal antibody (PD-1 mAb) as adjuvant immunotherapy after surgery was also assessed. PD-1-I RDyc800CW was developed and examined for its application in tumor imaging and image-guided tumor resection in an immunocompetent 4T1 mouse tumor model. Fluorescence molecular imaging was performed to monitor probe biodistribution and intraoperative imaging. Bioluminescence imaging was performed to monitor tumor growth and evaluate postsurgical tumor residuals, recurrences, and metastases. The PD-1-IRDye800CW exhibited a specific signal at the tumor region compared with the IgG control. Furthermore, PD-1-IRDye800CW-guided surgery combined with PD-1 adjuvant immunotherapy inhibited tumor rcgrowth and microtumor metastases and thus improved survival rate. Our study demonstrates the feasibility of using PD-1-IRDye800CW for breast tumor imaging and image-guided tumor resection. Moreover, PD-1 mAb adjuvant immunotherapy reduces cancer recurrences and metastases emanating from tumor residuals.
KeywordPd-1 Programmed Cell Death-1 Near-infrared Fluorescence (Nirf) Breast Cancer Image-guided Surgery Immunotherapy Fluorescence Imaging
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.2147/IJN.S149235
WOS KeywordCANCER-IMMUNOTHERAPY ; BREAST-CANCER ; ANTI-PD-L1 ANTIBODY ; ADVANCED MELANOMA ; SAFETY ; RESPONSES ; EXPRESSION ; BLOCKADE ; LYMPHOCYTES ; NIVOLUMAB
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81227901 ; Research and Development Program of China (973)(2014CB748600 ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; Beijing Natural Science Foundation(Z16110200010000) ; Peking University Third Hospital(BYSY2015023) ; China Postdoctoral Science Foundation(2013M530014) ; Cancer Prevention Research Institute of Texas(RP130145) ; US Department of Defense(W81XWH-13-1-0318) ; Welch Foundation(1-1751) ; Mary Kay Foundation(073.14) ; 81470083 ; 2015CB755500) ; 81527805 ; 81571810 ; 61231004 ; 81771846 ; 81201186)
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000415814100002
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/19584
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Radiol, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Dept Ultrasound, Beijing, Peoples R China
5.Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
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Du, Yang,Sun, Ting,Liang, Xiaolong,et al. Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12(12):8337-8351.
APA Du, Yang.,Sun, Ting.,Liang, Xiaolong.,Li, Yuan.,Jin, Zhengyu.,...&Tian, Jie.(2017).Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model.INTERNATIONAL JOURNAL OF NANOMEDICINE,12(12),8337-8351.
MLA Du, Yang,et al."Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model".INTERNATIONAL JOURNAL OF NANOMEDICINE 12.12(2017):8337-8351.
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