CASIA OpenIR  > 脑网络组研究中心
he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects
Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.
2015-06
发表期刊Scientific reports
期号5页码:10105
摘要The influence of catechol-o-methyltransferase (COMT) Val(158)Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of COMT Val(158)Met genotypes on the connection patterns of the brain network and working memory (WM) in healthy, young Val/Val and Met carrier subjects. There were significant differences in the performance level on the 2-back WM task between the different COMT genotypes: Val/Val individuals exhibited a higher correct rate compared to the Met carriers. A two-sample t test was used to examine the differences in the eigenvector centrality maps, using age and gender as covariates of no interest, between the Val/Val and Met carriers. We found that the Val/Val individuals exhibited significantly higher eigenvector centrality compared to the Met carriers in the left parahippocampal cortex. Furthermore, a significantly positive correlation between the mean eigenvector centrality of the significant cluster and the correct rate of the 2-back WM task was observed. By using a voxel-wise data-driven method, our findings may provide plausible implications regarding individual differences in the genetic contribution of COMT Val158Met to the brain network and cognition.
关键词Catechol-o-methyltransferase Functional Network Parahippocampal Cortex
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20228
专题脑网络组研究中心
推荐引用方式
GB/T 7714
Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.. he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects[J]. Scientific reports,2015(5):10105.
APA Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T..(2015).he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects.Scientific reports(5),10105.
MLA Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.."he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects".Scientific reports .5(2015):10105.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.]的文章
百度学术
百度学术中相似的文章
[Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.]的文章
必应学术
必应学术中相似的文章
[Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。