he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects | |
Zhang, X; Li, J; Qin, W; Yu, C; Liu, B; Jiang, T | |
发表期刊 | Scientific reports |
2015-06 | |
期号 | 5页码:10105 |
摘要 | The influence of catechol-o-methyltransferase (COMT) Val(158)Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of COMT Val(158)Met genotypes on the connection patterns of the brain network and working memory (WM) in healthy, young Val/Val and Met carrier subjects. There were significant differences in the performance level on the 2-back WM task between the different COMT genotypes: Val/Val individuals exhibited a higher correct rate compared to the Met carriers. A two-sample t test was used to examine the differences in the eigenvector centrality maps, using age and gender as covariates of no interest, between the Val/Val and Met carriers. We found that the Val/Val individuals exhibited significantly higher eigenvector centrality compared to the Met carriers in the left parahippocampal cortex. Furthermore, a significantly positive correlation between the mean eigenvector centrality of the significant cluster and the correct rate of the 2-back WM task was observed. By using a voxel-wise data-driven method, our findings may provide plausible implications regarding individual differences in the genetic contribution of COMT Val158Met to the brain network and cognition. |
关键词 | Catechol-o-methyltransferase Functional Network Parahippocampal Cortex |
七大方向——子方向分类 | 脑网络分析 |
国重实验室规划方向分类 | 其他 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/20228 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
推荐引用方式 GB/T 7714 | Zhang, X,Li, J,Qin, W,et al. he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects[J]. Scientific reports,2015(5):10105. |
APA | Zhang, X,Li, J,Qin, W,Yu, C,Liu, B,&Jiang, T.(2015).he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects.Scientific reports(5),10105. |
MLA | Zhang, X,et al."he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects".Scientific reports .5(2015):10105. |
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