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he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects
Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.
Source PublicationScientific reports
2015-06
Issue5Pages:10105
AbstractThe influence of catechol-o-methyltransferase (COMT) Val(158)Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of COMT Val(158)Met genotypes on the connection patterns of the brain network and working memory (WM) in healthy, young Val/Val and Met carrier subjects. There were significant differences in the performance level on the 2-back WM task between the different COMT genotypes: Val/Val individuals exhibited a higher correct rate compared to the Met carriers. A two-sample t test was used to examine the differences in the eigenvector centrality maps, using age and gender as covariates of no interest, between the Val/Val and Met carriers. We found that the Val/Val individuals exhibited significantly higher eigenvector centrality compared to the Met carriers in the left parahippocampal cortex. Furthermore, a significantly positive correlation between the mean eigenvector centrality of the significant cluster and the correct rate of the 2-back WM task was observed. By using a voxel-wise data-driven method, our findings may provide plausible implications regarding individual differences in the genetic contribution of COMT Val158Met to the brain network and cognition.
KeywordCatechol-o-methyltransferase Functional Network Parahippocampal Cortex
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20228
Collection脑网络组研究中心
Recommended Citation
GB/T 7714
Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.. he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects[J]. Scientific reports,2015(5):10105.
APA Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T..(2015).he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects.Scientific reports(5),10105.
MLA Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.."he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects".Scientific reports .5(2015):10105.
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