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Inter and intra-hemispheric structural imaging markers predict depression relapse after electroconvulsive therapy: a multisite study
Wade, Benjamin S. C.1,2; Sui, Jing3,4,5,6,7; Hellemann, Gerhard8; Leaver, Amber M.1; Espinoza, Randall T.2; Woods, Roger P.1; Abbott, Christopher C.9; Joshi, Shantanu H.1; Narr, Katherine L.1,2
Source PublicationTRANSLATIONAL PSYCHIATRY
2017-12-08
Volume7Issue:12Pages:1270
SubtypeArticle
AbstractRelapse of depression following treatment is high. Biomarkers predictive of an individual's relapse risk could provide earlier opportunities for prevention. Since electroconvulsive therapy (ECT) elicits robust and rapidly acting antidepressant effects, but has a > 50% relapse rate, ECT presents a valuable model for determining predictors of relapse-risk. Although previous studies have associated ECT-induced changes in brain morphometry with clinical response, longer-term outcomes have not been addressed. Using structural imaging data from 42 ECT-responsive patients obtained prior to and directly following an ECT treatment index series at two independent sites (UCLA: n = 17, age = 45.41 +/- 12.34 years; UNM: n = 25; age = 65.00 +/- 8.44), here we test relapse prediction within 6-months post-ECT. Random forests were used to predict subsequent relapse using singular and ratios of intra and inter-hemispheric structural imaging measures and clinical variables from pre-, post-, and pre-to-post ECT. Relapse risk was determined as a function of feature variation. Relapse was well-predicted both within site and when cohorts were pooled where top-performing models yielded balanced accuracies of 71-78%. Top predictors included cingulate isthmus asymmetry, pallidal asymmetry, the ratio of the paracentral to precentral cortical thickness and the ratio of lateral occipital to pericalcarine cortical thickness. Pooling cohorts and predicting relapse from post-treatment measures provided the best classification performances. However, classifiers trained on each age-disparate cohort were less informative for prediction in the held-out cohort. Post-treatment structural neuroimaging measures and the ratios of connected regions commonly implicated in depression pathophysiology are informative of relapse risk. Structural imaging measures may have utility for devising more personalized preventative medicine approaches.
Keyword.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1038/s41398-017-0020-7
WOS KeywordTRANSCRANIAL MAGNETIC STIMULATION ; LATE-LIFE DEPRESSION ; STAR-ASTERISK-D ; AMINOBUTYRIC-ACID CONCENTRATIONS ; MAJOR DEPRESSION ; CORTICAL EXCITABILITY ; GABA CONCENTRATIONS ; MATTER VOLUME ; RATING-SCALE ; CORE REPORT
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Institute of Mental Health(MH092301 ; National High Tech Program (863)(2015AA020513) ; MH110008 ; MH102743)
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000419038700004
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20270
Collection脑网络组研究中心
Affiliation1.Univ Calif Los Angeles, Dept Neurol, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90024 USA
2.Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
3.Mind Res Network, Albuquerque, NM USA
4.Lovelace Biomed & Environm Res Inst, Albuquerque, NM USA
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
7.Chinese Acad Sci, Ctr Excellence Brain Sci, Inst Automat, Beijing, Peoples R China
8.Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst, Los Angeles, CA 90024 USA
9.Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA
Recommended Citation
GB/T 7714
Wade, Benjamin S. C.,Sui, Jing,Hellemann, Gerhard,et al. Inter and intra-hemispheric structural imaging markers predict depression relapse after electroconvulsive therapy: a multisite study[J]. TRANSLATIONAL PSYCHIATRY,2017,7(12):1270.
APA Wade, Benjamin S. C..,Sui, Jing.,Hellemann, Gerhard.,Leaver, Amber M..,Espinoza, Randall T..,...&Narr, Katherine L..(2017).Inter and intra-hemispheric structural imaging markers predict depression relapse after electroconvulsive therapy: a multisite study.TRANSLATIONAL PSYCHIATRY,7(12),1270.
MLA Wade, Benjamin S. C.,et al."Inter and intra-hemispheric structural imaging markers predict depression relapse after electroconvulsive therapy: a multisite study".TRANSLATIONAL PSYCHIATRY 7.12(2017):1270.
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