| Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis | |
Du, Yuhui1,2; Fryer, Susanna L.3,4; Fu, Zening1; Lin, Dongdong1; Sui, Jing1,5,6 ; Chen, Jiayu1; Damaraju, Eswar1; Mennigen, Eva1,7; Stuart, Barbara3; Loewy, Rachel L.3; Mathalon, Daniel H.3,4; Calhoun, Vince D.1,7
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| Source Publication | NEUROIMAGE
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| ISSN | 1053-8119 |
| 2018-10-15 | |
| Volume | 180Pages:632-645 |
| Corresponding Author | Du, Yuhui(ydu@mrn.org) |
| Abstract | Individuals at clinical high-risk (CHR) for psychosis are characterized by attenuated psychotic symptoms. Only a minority of CHR individuals convert to full-blown psychosis. Therefore, there is a strong interest in identifying neurobiological abnormalities underlying the psychosis risk syndrome. Dynamic functional connectivity (DFC) captures time-varying connectivity over short time scales, and has the potential to reveal complex brain functional organization. Based on resting-state functional magnetic resonance imaging (fMRI) data from 70 healthy controls (HCs), 53 CHR individuals, and 58 early illness schizophrenia (ESZ) patients, we applied a novel group information guided ICA (GIG-ICA) to estimate inherent connectivity states from DFC, and then investigated group differences. We found that ESZ patients showed more aberrant connectivities and greater alterations than CHR individuals. Results also suggested that disease-related connectivity states occurred in CHR and ESZ groups. Regarding the dominant state with the highest contribution to dynamic connectivity, ESZ patients exhibited greater impairments than CHR individuals primarily in the cerebellum, frontal cortex, thalamus and temporal cortex, while CHR and ESZ populations shared common aberrances mainly in the supplementary motor area, parahippocampal gyrus and postcentral cortex. CHR-specific changes were also found in the connections between the superior frontal gyrus and calcarine cortex in the dominant state. Our findings suggest that CHR individuals generally show an intermediate functional connectivity pattern between HCs and SZ patients but also have unique connectivity alterations. |
| Keyword | fMRI Dynamic functional connectivity Connectivity state ICA Schizophrenia Clinical high-risk |
| DOI | 10.1016/j.neuroimage.2017.10.022 |
| WOS Keyword | TIME-VARYING CONNECTIVITY ; GLOBAL SIGNAL REGRESSION ; RESTING-STATE NETWORKS ; GIG-ICA APPLICATION ; ULTRA-HIGH-RISK ; BRAIN CONNECTIVITY ; PRODROMAL SYMPTOMS ; WORKING-MEMORY ; MENTAL STATE ; FMRI |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Institutes of Health[5P20RR021938/P20GM103472] ; National Institutes of Health[R01EB020407] ; National Science Foundation[1539067] ; National Institute of Mental Health[R01MH076989] ; National Natural Science Foundation of China[61703253] ; Natural Science Foundation of Shanxi[2016021077] ; National Institutes of Health[5P20RR021938/P20GM103472] ; National Institutes of Health[R01EB020407] ; National Science Foundation[1539067] ; National Institute of Mental Health[R01MH076989] ; National Natural Science Foundation of China[61703253] ; Natural Science Foundation of Shanxi[2016021077] |
| Funding Organization | National Institutes of Health ; National Science Foundation ; National Institute of Mental Health ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi |
| WOS Research Area | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000443271100025 |
| Publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/20272 |
| Collection | 脑网络组研究 |
| Corresponding Author | Du, Yuhui |
| Affiliation | 1.Mind Res Network, 1101 Yale Blvd NE, Albuquerque, NM 87131 USA 2.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China 3.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA 4.San Francisco VA Healthcare Syst, Mental Hlth Serv, San Francisco, CA USA 5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 7.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA |
| Recommended Citation GB/T 7714 | Du, Yuhui,Fryer, Susanna L.,Fu, Zening,et al. Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis[J]. NEUROIMAGE,2018,180:632-645. |
| APA | Du, Yuhui.,Fryer, Susanna L..,Fu, Zening.,Lin, Dongdong.,Sui, Jing.,...&Calhoun, Vince D..(2018).Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis.NEUROIMAGE,180,632-645. |
| MLA | Du, Yuhui,et al."Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis".NEUROIMAGE 180(2018):632-645. |
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