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CREB-BDNF Pathway Influences Alcohol Cue-Elicited Hyperactivation in Drinkers
Jiayu Chen; Kent E. Hutchison; Vince D. Calhoun; Eric Claus; Jessica A. Turner; Sui Jing(隋婧); Jingyu Liu
2015
会议名称Huamn Brin Mapping
会议日期2015-8
会议地点USA
摘要
Alcohol dependence (AD) is suggested to have polygenic risk factors and also exhibits neurological complications, strongly encouraging a translational study to explore the associations between aggregates of genetic variants and brain function alterations related to alcohol use. In this study, we used a semiblind multivariate approach, parallel independent component analysis with multiple references (pICA-MR) to investigate relationships of genome-wide single nucleotide polymorphisms (SNPs) with alcohol cue elicited brain activations in 326 healthy drinkers. The genetic component derived from the CREB-BDNF pathway reference was significantly associated (r = −0.36, p = 2.98×10−11) with an imaging component reflecting hyperactivation in precuneus, superior parietal lobule, and posterior cingulate for drinkers with more severe AD scores. The highlighted brain regions participate in many cognitive processes and have been robustly implicated in craving-related studies. The genetic factor highlighted the CREB and BDNF references, as well as other genes including GRM5, GRM7, GRID1, GRIN2A, PRKCA and PRKCB. Ingenuity Pathway Analysis indicated that the genetic component was enriched in synaptic plasticity, GABA and protein kinase A signaling. In summary, our findings suggest genetic variations in various neural plasticity and signaling pathways partially explain the variance of precuneus reactivity to alcohol cue which appears to be associated with AD severity.
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收录类别SCI
文献类型会议论文
条目标识符http://ir.ia.ac.cn/handle/173211/20301
专题脑网络组研究中心
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Jiayu Chen,Kent E. Hutchison,Vince D. Calhoun,et al. CREB-BDNF Pathway Influences Alcohol Cue-Elicited Hyperactivation in Drinkers[C],2015.
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