CASIA OpenIR  > 脑网络组研究中心
Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia
Fang, Xiaojing1; Wang, Yulin2; Cheng, Luqi1; Zhang, Yuanchao1; Zhou, Yuan3,4; Wu, Shihao5; Huang, Huan5; Zou, Jilin5; Chen, Cheng5; Chen, Jun6; Wang, Huiling5,7; Jiang, Tianzi1,8,9,10,11
2018-04-01
发表期刊BRAIN IMAGING AND BEHAVIOR
卷号12期号:2页码:335-344
文章类型Article
摘要Working memory (WM) deficit is a core feature of schizophrenia and is characterized by abnormal functional integration in the prefrontal cortex, including the dorsolateral prefrontal cortex (dLPFC), dorsal anterior cingulate cortex (dACC), and ventrolateral prefrontal cortex (vLPFC). However, the specific mechanism by which the abnormal neuronal circuits that involve these brain regions contribute to this deficit is still unclear. Therefore, this study focused on these regions and sought to answer which abnormal causal relationships in these regions can be linked to impaired WM in schizophrenia. We used spectral dynamic causal modeling to estimate directed (effective) connectivity between these regions based on resting-state functional magnetic resonance imaging data from healthy control (HC) subjects and patients with first-episode schizophrenia (FES). By comparing these effective connections in the controls and patients, we found that the effective connectivity from the dACC to the dLPFC and from the right dLPFC to the left vLPFC was weaker in the FES group than in the HC group. Furthermore, these effective connections displayed a positive correlation with WM performance in the HCs. However, in the FES patients, the effective connectivity from the dACC to the dLPFC was not correlated with WM performance, and the effective connectivity from the right dLPFC to the left vLPFC was negatively correlated with WM performance. These results could be explained by an aberrant top-down mechanism of WM processing and provide new evidence for the dysconnectivity hypothesis of schizophrenia.
关键词Resting-state Fmri Effective Connectivity Schizophrenia Spectral Dynamic Causal Modeling Working Memory Deficit
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-017-9692-0
关键词[WOS]ALTERED EFFECTIVE CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; COGNITIVE CONTROL ; SYNAPTIC PLASTICITY ; CORTEX ; FMRI ; NETWORK ; DISCONNECTION ; DYSFUNCTION ; ACTIVATION
收录类别SCI ; SSCI
语种英语
项目资助者National Basic Research Program of China(2011CB707800) ; National Natural Science Foundation of China(91132301) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2012075) ; Plan A of Science and Technology Support Program from Science and Technology Department of Sichuan Province(2014SZ0014) ; Natural Science Foundation of Hubei Province(2014CFB732)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000429029000004
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20323
专题脑网络组研究中心
作者单位1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Sichuan, Peoples R China
2.Vrije Univ Brussel, Fac Psychol & Educ Sci, Dept Expt & Appl Psychol, Res Grp Biol Psychol, Brussels, Belgium
3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
5.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan, Hubei, Peoples R China
6.Wuhan Univ, Dept Radiol, Renmin Hosp, Wuhan, Hubei, Peoples R China
7.Hubei Prov Key Lab Dev Originated Dis, Wuhan, Hubei, Peoples R China
8.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
10.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China
11.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
推荐引用方式
GB/T 7714
Fang, Xiaojing,Wang, Yulin,Cheng, Luqi,et al. Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia[J]. BRAIN IMAGING AND BEHAVIOR,2018,12(2):335-344.
APA Fang, Xiaojing.,Wang, Yulin.,Cheng, Luqi.,Zhang, Yuanchao.,Zhou, Yuan.,...&Jiang, Tianzi.(2018).Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia.BRAIN IMAGING AND BEHAVIOR,12(2),335-344.
MLA Fang, Xiaojing,et al."Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia".BRAIN IMAGING AND BEHAVIOR 12.2(2018):335-344.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fang, Xiaojing]的文章
[Wang, Yulin]的文章
[Cheng, Luqi]的文章
百度学术
百度学术中相似的文章
[Fang, Xiaojing]的文章
[Wang, Yulin]的文章
[Cheng, Luqi]的文章
必应学术
必应学术中相似的文章
[Fang, Xiaojing]的文章
[Wang, Yulin]的文章
[Cheng, Luqi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。