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INTERACTION EFFECT BETWEEN 5-HTTLPR AND HTR1A RS6295 POLYMORPHISMS ON THE FRONTOPARIETAL NETWORK
Long, Haixia1,2,3; Liu, Bing2,3; Wang, Chao4; Zhang, Xiaolong2,3; Li, Jin2,3; Yu, Chunshui5; Jiang, Tianzi2,3,4,6
2017-10-24
发表期刊NEUROSCIENCE
卷号362期号:362页码:239-247
文章类型Article
摘要network; Previous studies have shown a close relationship between the serotonin system and working memory (WM), but the neural mechanism for the role of the serotonin system on the WM is unclear. The frontoparietal network is involved in WM and is associated with the serotonin system. Therefore, this study investigated the interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the frontoparietal network obtained from the independent component analysis in a large, young Chinese sample population. The current study found a significant interaction effect of 5-HTTLPR and rs6295 on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Moreover, the mean connectivity in the right inferior parietal lobule was positively correlated with WM performance. These brain network analysis findings could provide a new perspective on the neural mechanisms of gene-gene interactions and on individual differences in cognitive functions. (C) 2017 Published by Elsevier Ltd on behalf of IBRO.
关键词5-httlpr Htr1a Rs6295 Frontoparietal Network Gene-gene Interaction Resting-state Network
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neuroscience.2017.08.003
关键词[WOS]WORKING-MEMORY PERFORMANCE ; MAJOR DEPRESSIVE DISORDER ; DEFAULT MODE NETWORK ; KNOCK-OUT MICE ; SEROTONIN TRANSPORTER ; PREFRONTAL CORTEX ; 5-HT1A RECEPTOR ; HUMAN BRAIN ; GENETIC POLYMORPHISMS ; CHINESE POPULATION
收录类别SCI
语种英语
项目资助者National Key Research and Development Program(2016YFC0904300) ; National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301 ; Beijing Nova Program(2010806) ; the Natural Science Foundation of Zhejiang Province, China(LQ15F030005) ; 91232718 ; 61503338)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000412382100021
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20324
专题脑网络组研究中心
作者单位1.Zhejiang Univ Technol, Coll Comp Sci & Technol, Hangzhou 310023, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab Neuroinformat, Chengdu 610054, Sichuan, Peoples R China
5.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
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Long, Haixia,Liu, Bing,Wang, Chao,et al. INTERACTION EFFECT BETWEEN 5-HTTLPR AND HTR1A RS6295 POLYMORPHISMS ON THE FRONTOPARIETAL NETWORK[J]. NEUROSCIENCE,2017,362(362):239-247.
APA Long, Haixia.,Liu, Bing.,Wang, Chao.,Zhang, Xiaolong.,Li, Jin.,...&Jiang, Tianzi.(2017).INTERACTION EFFECT BETWEEN 5-HTTLPR AND HTR1A RS6295 POLYMORPHISMS ON THE FRONTOPARIETAL NETWORK.NEUROSCIENCE,362(362),239-247.
MLA Long, Haixia,et al."INTERACTION EFFECT BETWEEN 5-HTTLPR AND HTR1A RS6295 POLYMORPHISMS ON THE FRONTOPARIETAL NETWORK".NEUROSCIENCE 362.362(2017):239-247.
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