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INTERACTION EFFECT BETWEEN 5-HTTLPR AND HTR1A RS6295 POLYMORPHISMS ON THE FRONTOPARIETAL NETWORK
Long, Haixia1,2,3; Liu, Bing2,3; Wang, Chao4; Zhang, Xiaolong2,3; Li, Jin2,3; Yu, Chunshui5; Jiang, Tianzi2,3,4,6
Source PublicationNEUROSCIENCE
2017-10-24
Volume362Issue:362Pages:239-247
SubtypeArticle
Abstractnetwork; Previous studies have shown a close relationship between the serotonin system and working memory (WM), but the neural mechanism for the role of the serotonin system on the WM is unclear. The frontoparietal network is involved in WM and is associated with the serotonin system. Therefore, this study investigated the interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the frontoparietal network obtained from the independent component analysis in a large, young Chinese sample population. The current study found a significant interaction effect of 5-HTTLPR and rs6295 on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Moreover, the mean connectivity in the right inferior parietal lobule was positively correlated with WM performance. These brain network analysis findings could provide a new perspective on the neural mechanisms of gene-gene interactions and on individual differences in cognitive functions. (C) 2017 Published by Elsevier Ltd on behalf of IBRO.
Keyword5-httlpr Htr1a Rs6295 Frontoparietal Network Gene-gene Interaction Resting-state Network
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neuroscience.2017.08.003
WOS KeywordWORKING-MEMORY PERFORMANCE ; MAJOR DEPRESSIVE DISORDER ; DEFAULT MODE NETWORK ; KNOCK-OUT MICE ; SEROTONIN TRANSPORTER ; PREFRONTAL CORTEX ; 5-HT1A RECEPTOR ; HUMAN BRAIN ; GENETIC POLYMORPHISMS ; CHINESE POPULATION
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program(2016YFC0904300) ; National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301 ; Beijing Nova Program(2010806) ; the Natural Science Foundation of Zhejiang Province, China(LQ15F030005) ; 91232718 ; 61503338)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000412382100021
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20324
Collection脑网络组研究中心
Affiliation1.Zhejiang Univ Technol, Coll Comp Sci & Technol, Hangzhou 310023, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab Neuroinformat, Chengdu 610054, Sichuan, Peoples R China
5.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Long, Haixia,Liu, Bing,Wang, Chao,et al. INTERACTION EFFECT BETWEEN 5-HTTLPR AND HTR1A RS6295 POLYMORPHISMS ON THE FRONTOPARIETAL NETWORK[J]. NEUROSCIENCE,2017,362(362):239-247.
APA Long, Haixia.,Liu, Bing.,Wang, Chao.,Zhang, Xiaolong.,Li, Jin.,...&Jiang, Tianzi.(2017).INTERACTION EFFECT BETWEEN 5-HTTLPR AND HTR1A RS6295 POLYMORPHISMS ON THE FRONTOPARIETAL NETWORK.NEUROSCIENCE,362(362),239-247.
MLA Long, Haixia,et al."INTERACTION EFFECT BETWEEN 5-HTTLPR AND HTR1A RS6295 POLYMORPHISMS ON THE FRONTOPARIETAL NETWORK".NEUROSCIENCE 362.362(2017):239-247.
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