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APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults
Zhang, Ningnannan1,2; Liu, Huaigui1,2; Qin, Wen1,2; Liu, Bing3; Jiang, Tianzi3; Yu, Chunshui1,2
Source PublicationCEREBRAL CORTEX
2017-10-01
Volume27Issue:10Pages:4797-4805
SubtypeArticle
AbstractGenetic variations of APOE and KIBRA have been associated with human memory and Alzheimer's disease. APOE and KIBRA can jointly modulate glutamate receptor to influence long-term potentiation; however, their interactions on brain functional connectivity remain unknown. Here, we investigated additive and epistatic interactions between APOE and KIBRA (rs17070145) on brain functional connectivity density (FCD) in 267 healthy young adults. A voxel-based FCD analysis was performed to identify brain regions with significant APOE-KIBRA interaction. Additive effects showed decreased FCD in the left parahippocampal gyrus and the right middle temporal gyrus and increased FCD in the bilateral middle occipital gyri, with the increase of the number of the risk-alleles of APOE and KIBRA. Epistatic effects showed APOE x KIBRA interaction in the FCD of the dorsolateral prefrontal cortex (DLPFC). The FCD of the DLPFC showed APOE risk-allele-dependent reduction (epsilon 2 > epsilon 3 > epsilon 4) in KIBRA TT homozygotes, but APOE risk-allele-dependent increase (epsilon 2 < epsilon 3 < epsilon 4) in KIBRA C-carriers. FCD differences were only significant between the 2 extreme subgroups in both additive and epistatic analyses. These findings suggest that APOE and KIBRA have region-dependent additive and epistatic interactions on brain connectivity in healthy young adults.
KeywordApoe Functional Connectivity Density Functional Magnetic Resonance Imaging Genetic Interaction Kibra
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1093/cercor/bhw276
WOS KeywordDORSOLATERAL PREFRONTAL CORTEX ; AGE-DEPENDENT ASSOCIATION ; ALZHEIMERS-DISEASE RISK ; WORKING-MEMORY ; EPSILON-4 ALLELE ; SYNAPTIC PLASTICITY ; HIPPOCAMPAL VOLUME ; GENE POLYMORPHISM ; RECEPTOR FUNCTION ; INDIVIDUALS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81301202 ; 81301217 ; 81425013 ; 91332113 ; 81271551)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000410394400010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20327
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ningnannan,Liu, Huaigui,Qin, Wen,et al. APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults[J]. CEREBRAL CORTEX,2017,27(10):4797-4805.
APA Zhang, Ningnannan,Liu, Huaigui,Qin, Wen,Liu, Bing,Jiang, Tianzi,&Yu, Chunshui.(2017).APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults.CEREBRAL CORTEX,27(10),4797-4805.
MLA Zhang, Ningnannan,et al."APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults".CEREBRAL CORTEX 27.10(2017):4797-4805.
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