Tissue microstructure estimation using a deep network inspired by a dictionary-based framework

doi:10.1016/j.media.2017.09.001

	Tissue microstructure estimation using a deep network inspired by a dictionary-based framework
	Ye, Chuyang1,2
发表期刊	MEDICAL IMAGE ANALYSIS
	2017-12-01
卷号	42 期号:42 页码:288-299
文章类型	Article
摘要	Diffusion magnetic resonance imaging (dMRI) captures the anisotropic pattern of water displacement in the neuronal tissue and allows noninvasive investigation of the complex tissue microstructure. A number of biophysical models have been proposed to relate the tissue organization with the observed diffusion signals, so that the tissue microstructure can be inferred. The Neurite Orientation Dispersion and Density Imaging (NODDI) model has been a popular choice and has been widely used for many neuroscientific studies. It models the diffusion signal with three compartments that are characterized by distinct diffusion properties, and the parameters in the model describe tissue microstructure. In NODDI, these parameters are estimated in a maximum likelihood framework, where the nonlinear model fitting is computationally intensive. Therefore, efforts have been made to develop efficient and accurate algorithms for NODDI microstructure estimation, which is still an open problem. In this work, we propose a deep network based approach that performs end-to-end estimation of NODDI microstructure, which is named Microstructure Estimation using a Deep Network (MEDN). MEDN comprises two cascaded stages and is motivated by the AMICO algorithm, where the NODDI microstructure estimation is formulated in a dictionary-based framework. The first stage computes the coefficients of the dictionary. It resembles the solution to a sparse reconstruction problem, where the iterative process in conventional estimation approaches is unfolded and truncated, and the weights are learned instead of predetermined by the dictionary. In the second stage, microstructure properties are computed from the output of the first stage, which resembles the weighted sum of normalized dictionary coefficients in AMICO, and the weights are also learned. Because spatial consistency of diffusion signals can be used to reduce the effect of noise, we also propose MEDN+, which is an extended version of MEDN. MEDN+ allows incorporation of neighborhood information by inserting a stage with learned weights before the MEDN structure, where the diffusion signals in the neighborhood of a voxel are processed. The weights in MEDN or MEDN+ are jointly learned from training samples that are acquired with diffusion gradients densely sampling the q space. We performed MEDN and MEDN+ on brain dMRI scans, where two shells each with 30 gradient directions were used, and measured their accuracy with respect to the gold standard. Results demonstrate that the proposed networks outperform the competing methods. (C) 2017 Elsevier B.V. All rights reserved.
关键词	Diffusion Mri Tissue Microstructure Noddi Sparse Reconstruction Deep Network
WOS标题词	Science & Technology ; Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.media.2017.09.001
关键词[WOS]	NEURITE ORIENTATION DISPERSION ; IN-DIFFUSION MRI ; WHITE-MATTER ; MULTIPLE-SCLEROSIS ; ALZHEIMERS-DISEASE ; AXON DIAMETER ; HUMAN BRAIN ; DENSITY ; NODDI ; MODEL
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(NSFC 61601461) ; 16 NIH Institutes and Centers - NIH Blueprint for Neuroscience Research(1U54MH091657) ; McDonnell Center for Systems Neuroscience at Washington University
WOS研究方向	Computer Science ; Engineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Computer Science, Artificial Intelligence ; Computer Science, Interdisciplinary Applications ; Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000415778100020
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/20338
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Intelligence Bldg 505,95 Zhongguancun East Rd, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
第一作者单位	中国科学院自动化研究所; 模式识别国家重点实验室
推荐引用方式 GB/T 7714	Ye, Chuyang. Tissue microstructure estimation using a deep network inspired by a dictionary-based framework[J]. MEDICAL IMAGE ANALYSIS,2017,42(42):288-299.
APA	Ye, Chuyang.(2017).Tissue microstructure estimation using a deep network inspired by a dictionary-based framework.MEDICAL IMAGE ANALYSIS,42(42),288-299.
MLA	Ye, Chuyang."Tissue microstructure estimation using a deep network inspired by a dictionary-based framework".MEDICAL IMAGE ANALYSIS 42.42(2017):288-299.

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