Segmentation of the Cerebellar Peduncles Using a Random Forest Classifier and a Multi-object Geometric Deformable Model: Application to Spinocerebellar Ataxia Type 6

	Segmentation of the Cerebellar Peduncles Using a Random Forest Classifier and a Multi-object Geometric Deformable Model: Application to Spinocerebellar Ataxia Type 6
	Ye, Chuyang; Yang, Zhen; Ying, Sarah; Prince, Jerry
发表期刊	Neuroinformatics
	2015-07
卷号	13 期号:3 页码:367-381
摘要	The cerebellar peduncles, comprising the superior cerebellar peduncles (SCPs), the middle cerebellar peduncle (MCP), and the inferior cerebellar peduncles (ICPs), are white matter tracts that connect the cerebellum to other parts of the central nervous system. Methods for automatic segmentation and quantification of the cerebellar peduncles are needed for objectively and efficiently studying their structure and function. Diffusion tensor imaging (DTI) provides key information to support this goal, but it remains challenging because the tensors change dramatically in the decussation of the SCPs (dSCP), the region where the SCPs cross. This paper presents an automatic method for segmenting the cerebellar peduncles, including the dSCP. The method uses volumetric segmentation concepts based on extracted DTI features. The dSCP and noncrossing portions of the peduncles are modeled as separate objects, and are initially classified using a random forest classifier together with the DTI features. To obtain geometrically correct results, a multi-object geometric deformable model is used to refine the random forest classification. The method was evaluated using a leave-one-out crossvalidation on five control subjects and four patients with spinocerebellar ataxia type 6 (SCA6). It was then used to evaluate group differences in the peduncles in a population of 32 controls and 11 SCA6 patients. In the SCA6 group, we have observed significant decreases in the volumes of the dSCP and the ICPs and significant increases in the mean diffusivity in the noncrossing SCPs, the MCP, and the ICPs. These results are consistent with a degeneration of the cerebellar peduncles in SCA6 patients.
关键词	Cerebellar Peduncles Random Forest Classifier
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/20340
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	Johns Hopkins University
推荐引用方式 GB/T 7714	Ye, Chuyang,Yang, Zhen,Ying, Sarah,et al. Segmentation of the Cerebellar Peduncles Using a Random Forest Classifier and a Multi-object Geometric Deformable Model: Application to Spinocerebellar Ataxia Type 6[J]. Neuroinformatics,2015,13(3):367-381.
APA	Ye, Chuyang,Yang, Zhen,Ying, Sarah,&Prince, Jerry.(2015).Segmentation of the Cerebellar Peduncles Using a Random Forest Classifier and a Multi-object Geometric Deformable Model: Application to Spinocerebellar Ataxia Type 6.Neuroinformatics,13(3),367-381.
MLA	Ye, Chuyang,et al."Segmentation of the Cerebellar Peduncles Using a Random Forest Classifier and a Multi-object Geometric Deformable Model: Application to Spinocerebellar Ataxia Type 6".Neuroinformatics 13.3(2015):367-381.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
NEIN.pdf（3506KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载