Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data

	Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data
	Liu ZY(刘振宇)
发表期刊	European Radiology
	2017-10
期号	27 页码:4153–4162
摘要	Objective To identify the white matter (WM) impairments of the antiretroviral therapy (ART)-naïve HIV patients by conducting a multivariate pattern analysis (MVPA) of Diffusion Tensor Imaging (DTI) data Methods We enrolled 33 ART-naïve HIV patients and 32 Normal controls in the current study. Firstly, the DTI metrics in whole brain WM tracts were extracted for each subject and feed into the Least Absolute Shrinkage and Selection Operators procedure (LASSO)-Logistic regression model to identify the impaired WM tracts. Then, Support Vector Machines (SVM) model was constructed based on the DTI metrics in the impaired WM tracts to make HIV-control group classification. Pearson correlations between the WM impairments and HIV clinical statics were also investigated. Results Extensive HIV-related impairments were observed in the WM tracts associated with motor function, the corpus callosum (CC) and the frontal WM. With leave-one-out cross validation, accuracy of 83.08% (P=0.002) and the area under the Receiver Operating Characteristic curve of 0.9110 were obtained in the SVM classification model. The impairments of the CC were significantly correlated with the HIV clinic statics. Conclusion The MVPA was sensitive to detect the HIV-related WM changes. Our findings indicated that the MVPA had considerable potential in exploring the HIV-related WM impairments.
关键词	Dti
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/20346
专题	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Liu ZY. Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data[J]. European Radiology,2017(27):4153–4162.
APA	Liu ZY.(2017).Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data.European Radiology(27),4153–4162.
MLA	Liu ZY."Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data".European Radiology .27(2017):4153–4162.

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