CASIA OpenIR  > 中国科学院分子影像重点实验室
Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats
Chu TH; Du Yang; Wu W
Source PublicationExperimental Neurology
2008-08
Volume212Issue:2Pages:562
Abstract

In the present study, we compared the effects of implanting peripheral sensory nerve and motor nerve on motoneuron survival and regeneration after spinal root avulsion in adult rats. Our results showed that 116% more motoneurons regenerated axons into the motor than the sensory nerve graft and 59% of motoneurons survived in the motor nerve-implanted group compared to 48% in the sensory nerve-implanted group. We demonstrated by real time PCR that levels of BDNF and GDNF mRNA were significantly higher in the motor than the sensory nerve five days after implantation into the spinal cord. This may account for the superiority of motor over sensory nerve in promoting motor axon regeneration and motoneuron survival. Lastly, we also showed that implanting two sensory nerves enhances motoneuron regeneration over implanting a single nerve.

KeywordAvulsion Peripheral Nerve Implantation Bdnf Bdnf
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20497
Collection中国科学院分子影像重点实验室
Corresponding AuthorWu W
Recommended Citation
GB/T 7714
Chu TH,Du Yang,Wu W. Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats[J]. Experimental Neurology,2008,212(2):562.
APA Chu TH,Du Yang,&Wu W.(2008).Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats.Experimental Neurology,212(2),562.
MLA Chu TH,et al."Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats".Experimental Neurology 212.2(2008):562.
Files in This Item: Download All
File Name/Size DocType Version Access License
1-s2.0-S001448860800(311KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chu TH]'s Articles
[Du Yang]'s Articles
[Wu W]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chu TH]'s Articles
[Du Yang]'s Articles
[Wu W]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chu TH]'s Articles
[Du Yang]'s Articles
[Wu W]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S0014488608002161-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.