Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study

doi:10.1007/s11682-016-9597-3

CASIA OpenIR > 复杂系统管理与控制国家重点实验室 > 影像分析与机器视觉

	Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study
	Wang, Jieqiong1,2 ; Li, Ting 3; Zhou, Peng 1,2; Wang, Ningli 4; Xian, Junfang 3; He, Huiguang1,2,5
发表期刊	BRAIN IMAGING AND BEHAVIOR
	2017-08-01
卷号	11 期号:4 页码:1154-1163
文章类型	Article
摘要	To explore the alterations of functional connectivity (FC) and connections within and between the subnetworks of the visual network and the default mode network in glaucoma. We applied the independent component analysis to obtain two resting-state networks (RSNs), which were the visual network and the default mode network (DMN), from the resting-state fMRI data of 25 primary open-angle glaucoma (POAG) patients and 25 well-matched normal controls. Then FC analysis was performed to obtain the altered FC within the RSNs, whereas the functional network connectivity (FNC) analysis was performed within and between these two RSNs. The abnormalities were correlated with clinical measures in glaucoma to investigate the abnormality-clinical relationship. FC analysis showed that the FC in the occipital pole of the visual network was decreased in POAG patients while no alterations were found in the FC of the DMN in patients. FNC analysis of connections within the RSNs found that two of the three connections within the visual network were decreased while no connection alterations were found within the DMN. FNC analysis of connections between these two RSNs found two increased connections and one decreased connection. The decreased connection between these two RSNs was positively correlated with the visual field mean deviation. These findings shed light on the importance of the reorganization of resting state networks in glaucoma mechanism, which may facilitate the understanding of glaucoma.
关键词	Subnetwork Independent Component Analysis Glaucoma Functional Connectivity Functional Network Connectivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1007/s11682-016-9597-3
关键词[WOS]	LATERAL GENICULATE-NUCLEUS ; AGE-RELATED-CHANGES ; BLIND SEPARATION ; OPTIC-NERVE ; BRAIN ; STIMULATION ; COMPONENTS ; SCHIZOPHRENIA ; ABNORMALITIES ; RESPONSES
URL	查看原文
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(61271151 ; Youth Innovation Promotion Association CAS ; 91520202 ; 81571649)
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000407840500022
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/20596
专题	复杂系统管理与控制国家重点实验室_影像分析与机器视觉
作者单位	1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China 4.Capital Med Univ, Beijing Tongren Hosp, Dept Ophthalmol, Beijing, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Wang, Jieqiong,Li, Ting,Zhou, Peng,et al. Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):1154-1163.
APA	Wang, Jieqiong,Li, Ting,Zhou, Peng,Wang, Ningli,Xian, Junfang,&He, Huiguang.(2017).Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study.BRAIN IMAGING AND BEHAVIOR,11(4),1154-1163.
MLA	Wang, Jieqiong,et al."Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study".BRAIN IMAGING AND BEHAVIOR 11.4(2017):1154-1163.