CASIA OpenIR  > 中国科学院分子影像重点实验室
The implication of salience network abnormalities in young male adult smokers
Li, Yangding1,2; Yuan, Kai1,2,3; Guan, Yanyan1,2; Cheng, Jiadong1,2; Bi, Yanzhi1,2; Shi, Sha1,2; Xue, Ting4; Lu, Xiaoqi3; Qin, Wei1,2; Yu, Dahua3; Tian, Jie1,2,5
Source PublicationBRAIN IMAGING AND BEHAVIOR
2017-08-01
Volume11Issue:4Pages:943-953
SubtypeArticle
AbstractStudying the neural correlates of smoking behaviors in young adulthood is of great importance to improve treatment outcomes. In previous addiction studies, the important roles of the salience network (SN) in drug cue processing and cognitive control have been revealed. Unfortunately, few studies focused on the resting-state functional connectivity and structural integrity abnormalities of SN in young adult smokers, and less is known about its association with smoking behaviors and cognitive control deficits. Thirty-one young male adult smokers and 30 age-, education- and gender-matched nonsmokers participated in this study. The structural and functional connectivity differences of SN were investigated between young adult smokers and nonsmokers by using diffusion tensor imaging (DTI) and resting-state functional connectivity (RSFC), which were then correlated with the smoking behavioral assessments (pack-years and Fagerstrom Test for Nicotine Dependence (FTND)) as well as impaired cognitive control measured by the Stroop task. Within SN, reduced RSFC and increased fractional anisotropy (FA) were found between the anterior cingulate cortex (ACC) and the right insula in young adult smokers relative to nonsmokers. The RSFC between the ACC and right insula was negatively correlated with the number of errors during the incongruent condition of the Stroop task in young adult smokers. Additionally, the right insula-ACC RSFC was negatively correlated with pack-years in young adult smokers. Our results revealed abnormal RSFC and structural integrity within the SN in young adult smokers, which shed new insights into the neural mechanism of nicotine dependence.
KeywordSalience Network Resting-state Functional Connectivity Diffusion Tensor Imaging Stroop Task Young Adult Smoker
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-016-9568-8
WOS KeywordANTERIOR CINGULATE CORTEX ; STATE FUNCTIONAL CONNECTIVITY ; DEFAULT MODE NETWORK ; CIGARETTE-SMOKING ; COGNITIVE-DEVELOPMENT ; RESTING-STATE ; STROOP TASK ; FRONTOSTRIATAL CIRCUITS ; NICOTINE ADDICTION ; BRAIN REACTIVITY
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81571751 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03 ; China Post-doctoral Science Foundation(2014 M552416) ; 81571753 ; JB121405) ; 2014QDL002) ; 61502376 ; 81401478 ; 81401488 ; 81470816 ; 81471737 ; 81301281 ; 81271546 ; 81271549)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000407840500003
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20708
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Shaanxi, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Informat Proc Lab, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China
4.Inner Mongolia Univ Sci & Technol, Sch Math Phys & Biol Engn, Baotou 014010, Inner Mongolia, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Yangding,Yuan, Kai,Guan, Yanyan,et al. The implication of salience network abnormalities in young male adult smokers[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):943-953.
APA Li, Yangding.,Yuan, Kai.,Guan, Yanyan.,Cheng, Jiadong.,Bi, Yanzhi.,...&Tian, Jie.(2017).The implication of salience network abnormalities in young male adult smokers.BRAIN IMAGING AND BEHAVIOR,11(4),943-953.
MLA Li, Yangding,et al."The implication of salience network abnormalities in young male adult smokers".BRAIN IMAGING AND BEHAVIOR 11.4(2017):943-953.
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