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The implication of salience network abnormalities in young male adult smokers
Li, Yangding1,2; Yuan, Kai1,2,3; Guan, Yanyan1,2; Cheng, Jiadong1,2; Bi, Yanzhi1,2; Shi, Sha1,2; Xue, Ting4; Lu, Xiaoqi3; Qin, Wei1,2; Yu, Dahua3; Tian, Jie1,2,5
2017-08-01
发表期刊BRAIN IMAGING AND BEHAVIOR
卷号11期号:4页码:943-953
文章类型Article
摘要Studying the neural correlates of smoking behaviors in young adulthood is of great importance to improve treatment outcomes. In previous addiction studies, the important roles of the salience network (SN) in drug cue processing and cognitive control have been revealed. Unfortunately, few studies focused on the resting-state functional connectivity and structural integrity abnormalities of SN in young adult smokers, and less is known about its association with smoking behaviors and cognitive control deficits. Thirty-one young male adult smokers and 30 age-, education- and gender-matched nonsmokers participated in this study. The structural and functional connectivity differences of SN were investigated between young adult smokers and nonsmokers by using diffusion tensor imaging (DTI) and resting-state functional connectivity (RSFC), which were then correlated with the smoking behavioral assessments (pack-years and Fagerstrom Test for Nicotine Dependence (FTND)) as well as impaired cognitive control measured by the Stroop task. Within SN, reduced RSFC and increased fractional anisotropy (FA) were found between the anterior cingulate cortex (ACC) and the right insula in young adult smokers relative to nonsmokers. The RSFC between the ACC and right insula was negatively correlated with the number of errors during the incongruent condition of the Stroop task in young adult smokers. Additionally, the right insula-ACC RSFC was negatively correlated with pack-years in young adult smokers. Our results revealed abnormal RSFC and structural integrity within the SN in young adult smokers, which shed new insights into the neural mechanism of nicotine dependence.
关键词Salience Network Resting-state Functional Connectivity Diffusion Tensor Imaging Stroop Task Young Adult Smoker
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-016-9568-8
关键词[WOS]ANTERIOR CINGULATE CORTEX ; STATE FUNCTIONAL CONNECTIVITY ; DEFAULT MODE NETWORK ; CIGARETTE-SMOKING ; COGNITIVE-DEVELOPMENT ; RESTING-STATE ; STROOP TASK ; FRONTOSTRIATAL CIRCUITS ; NICOTINE ADDICTION ; BRAIN REACTIVITY
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(81571751 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03 ; China Post-doctoral Science Foundation(2014 M552416) ; 81571753 ; JB121405) ; 2014QDL002) ; 61502376 ; 81401478 ; 81401488 ; 81470816 ; 81471737 ; 81301281 ; 81271546 ; 81271549)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000407840500003
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20708
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Shaanxi, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Informat Proc Lab, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China
4.Inner Mongolia Univ Sci & Technol, Sch Math Phys & Biol Engn, Baotou 014010, Inner Mongolia, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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Li, Yangding,Yuan, Kai,Guan, Yanyan,et al. The implication of salience network abnormalities in young male adult smokers[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):943-953.
APA Li, Yangding.,Yuan, Kai.,Guan, Yanyan.,Cheng, Jiadong.,Bi, Yanzhi.,...&Tian, Jie.(2017).The implication of salience network abnormalities in young male adult smokers.BRAIN IMAGING AND BEHAVIOR,11(4),943-953.
MLA Li, Yangding,et al."The implication of salience network abnormalities in young male adult smokers".BRAIN IMAGING AND BEHAVIOR 11.4(2017):943-953.
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