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The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers
Yuan, Kai1,2,3; Yu, Dahua3; Bi, Yanzhi1,2; Wang, Ruonan1,2; Li, Min1,2; Zhang, Yajuan1,2; Dong, Minghao1,2; Zhai, Jinquan4; Li, Yangding5; Lu, Xiaoqi3; Tian, Jie1,2,6
2017-09-01
发表期刊HUMAN BRAIN MAPPING
卷号38期号:9页码:4644-4656
文章类型Article
摘要Although the activation of the prefrontal cortex (PFC) and the striatum had been found in smoking cue induced craving task, whether and how the functional interactions and white matter integrity between these brain regions contribute to craving processing during smoking cue exposure remains unknown. Twenty-five young male smokers and 26 age-and gender-matched nonsmokers participated in the smoking cue-reactivity task. Craving related brain activation was extracted and psychophysiological interactions (PPI) analysis was used to specify the PFC-efferent pathways contributed to smoking cue-induced craving. Diffusion tensor imaging (DTI) and probabilistic tractography was used to explore whether the fiber connectivity strength facilitated functional coupling of the circuit with the smoking cue-induced craving. The PPI analysis revealed the negative functional coupling of the left dorsolateral prefrontal cortex (DLPFC) and the caudate during smoking cue induced craving task, which positively correlated with the craving score. Neither significant activation nor functional connectivity in smoking cue exposure task was detected in nonsmokers. DTI analyses revealed that fiber tract integrity negatively correlated with functional coupling in the DLPFC-caudate pathway and activation of the caudate induced by smoking cue in smokers. Moreover, the relationship between the fiber connectivity integrity of the left DLPFC-caudate and smoking cue induced caudate activation can be fully mediated by functional coupling strength of this circuit in smokers. The present study highlighted the left DLPFC-caudate pathway in smoking cue-induced craving in smokers, which may reflect top-down prefrontal modulation of striatal reward processing in smoking cue induced craving processing. (C) 2017 Wiley Periodicals, Inc.
关键词Dorsolateral Prefrontal Cortex Caudate Smoker Craving Diffusion Tensor Imaging Psychophysiological Interactions
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.23690
关键词[WOS]TRANSCRANIAL MAGNETIC STIMULATION ; STATE FUNCTIONAL CONNECTIVITY ; COGNITIVE CONTROL DEFICITS ; INTERNET GAMING DISORDER ; WHITE-MATTER INTEGRITY ; YOUNG-ADULT SMOKERS ; RESTING-STATE ; DOPAMINE RELEASE ; SMOKING CUES ; PSYCHOPHYSIOLOGICAL INTERACTIONS
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81571751 ; Fundamental Research Funds for the Central Universities(JBG151207 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03) ; 81571753 ; JB161201) ; 61502376 ; 81401478 ; 81401488 ; 81470816 ; 81471737)
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000407014700026
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20709
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Inner Mongolia Univ Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Baotou 014010, Inner Mongolia, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Baotou 014010, Inner Mongolia, Peoples R China
4.Inner Mongolia Univ Sci & Technol, Affiliated Hosp 1, Baotou Med Coll, Dept Med Imaging, Baotou 014010, Inner Mongolia, Peoples R China
5.Guangxi Normal Univ, Guangxi Key Lab Multi Source Informat Min & Secur, Guilin, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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Yuan, Kai,Yu, Dahua,Bi, Yanzhi,et al. The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers[J]. HUMAN BRAIN MAPPING,2017,38(9):4644-4656.
APA Yuan, Kai.,Yu, Dahua.,Bi, Yanzhi.,Wang, Ruonan.,Li, Min.,...&Tian, Jie.(2017).The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers.HUMAN BRAIN MAPPING,38(9),4644-4656.
MLA Yuan, Kai,et al."The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers".HUMAN BRAIN MAPPING 38.9(2017):4644-4656.
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