CASIA OpenIR  > 中国科学院分子影像重点实验室
The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers
Yuan, Kai1,2,3; Yu, Dahua3; Bi, Yanzhi1,2; Wang, Ruonan1,2; Li, Min1,2; Zhang, Yajuan1,2; Dong, Minghao1,2; Zhai, Jinquan4; Li, Yangding5; Lu, Xiaoqi3; Tian, Jie1,2,6
Source PublicationHUMAN BRAIN MAPPING
2017-09-01
Volume38Issue:9Pages:4644-4656
SubtypeArticle
AbstractAlthough the activation of the prefrontal cortex (PFC) and the striatum had been found in smoking cue induced craving task, whether and how the functional interactions and white matter integrity between these brain regions contribute to craving processing during smoking cue exposure remains unknown. Twenty-five young male smokers and 26 age-and gender-matched nonsmokers participated in the smoking cue-reactivity task. Craving related brain activation was extracted and psychophysiological interactions (PPI) analysis was used to specify the PFC-efferent pathways contributed to smoking cue-induced craving. Diffusion tensor imaging (DTI) and probabilistic tractography was used to explore whether the fiber connectivity strength facilitated functional coupling of the circuit with the smoking cue-induced craving. The PPI analysis revealed the negative functional coupling of the left dorsolateral prefrontal cortex (DLPFC) and the caudate during smoking cue induced craving task, which positively correlated with the craving score. Neither significant activation nor functional connectivity in smoking cue exposure task was detected in nonsmokers. DTI analyses revealed that fiber tract integrity negatively correlated with functional coupling in the DLPFC-caudate pathway and activation of the caudate induced by smoking cue in smokers. Moreover, the relationship between the fiber connectivity integrity of the left DLPFC-caudate and smoking cue induced caudate activation can be fully mediated by functional coupling strength of this circuit in smokers. The present study highlighted the left DLPFC-caudate pathway in smoking cue-induced craving in smokers, which may reflect top-down prefrontal modulation of striatal reward processing in smoking cue induced craving processing. (C) 2017 Wiley Periodicals, Inc.
KeywordDorsolateral Prefrontal Cortex Caudate Smoker Craving Diffusion Tensor Imaging Psychophysiological Interactions
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.23690
WOS KeywordTRANSCRANIAL MAGNETIC STIMULATION ; STATE FUNCTIONAL CONNECTIVITY ; COGNITIVE CONTROL DEFICITS ; INTERNET GAMING DISORDER ; WHITE-MATTER INTEGRITY ; YOUNG-ADULT SMOKERS ; RESTING-STATE ; DOPAMINE RELEASE ; SMOKING CUES ; PSYCHOPHYSIOLOGICAL INTERACTIONS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81571751 ; Fundamental Research Funds for the Central Universities(JBG151207 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03) ; 81571753 ; JB161201) ; 61502376 ; 81401478 ; 81401488 ; 81470816 ; 81471737)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000407014700026
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20709
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Inner Mongolia Univ Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Baotou 014010, Inner Mongolia, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Baotou 014010, Inner Mongolia, Peoples R China
4.Inner Mongolia Univ Sci & Technol, Affiliated Hosp 1, Baotou Med Coll, Dept Med Imaging, Baotou 014010, Inner Mongolia, Peoples R China
5.Guangxi Normal Univ, Guangxi Key Lab Multi Source Informat Min & Secur, Guilin, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Kai,Yu, Dahua,Bi, Yanzhi,et al. The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers[J]. HUMAN BRAIN MAPPING,2017,38(9):4644-4656.
APA Yuan, Kai.,Yu, Dahua.,Bi, Yanzhi.,Wang, Ruonan.,Li, Min.,...&Tian, Jie.(2017).The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers.HUMAN BRAIN MAPPING,38(9),4644-4656.
MLA Yuan, Kai,et al."The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers".HUMAN BRAIN MAPPING 38.9(2017):4644-4656.
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