CASIA OpenIR  > 中国科学院分子影像重点实验室
Interaction of acupuncture treatment and manipulation laterality modulated by the default mode network
Niu, Xuan1,2; Zhang, Ming2; Liu, Zhenyu3; Bai, Lijun1,4; Sun, Chuanzhu1; Wang, Shan1; Wang, Xiaocui1; Chen, Zhen1; Chen, Hongyan5; Tian, Jie3
2016-12-01
发表期刊MOLECULAR PAIN
卷号13
文章类型Article
摘要Appropriate selection of ipsilateral or contralateral electroacupuncture (corresponding to the pain site) plays an important role in reaching its better curative effect; however, the involving brain mechanism still remains unclear. Compared with the heat pain model generally established in previous study, capsaicin pain model induces reversible cutaneous allodynia and is proved to be better simulating aspects of clinical nociceptive and neuropathic pain. In the current study, 24 subjects were randomly divided into two groups with a 2 x 2 factorial design: laterality (ipsi- or contralateral side, inter-subject) x treatment with counter-balanced at an interval of one week (verum and placebo electroacupuncture, within-subject). We observed subjective pain intensity and brain activations changes induced by capsaicin allodynia pain stimuli before and after electroacupuncture treatment at acupoint LI4 for 30 min. Analysis of variance results indicated that ipsilateral electroacupuncture treatment produced significant pain relief and wide brain signal suppressions in pain-related brain areas compared with contralateral electroacupuncture. We also found that verum electroacupuncture at either ipsi- or contralateral side to the pain site exhibited comparable significant magnitudes of analgesic effect. By contrast, placebo electroacupuncture elicited significant pain reductions only on the ipsilateral rather than contralateral side. It was inferred that placebo analgesia maybe attenuated on the region of the body (opposite to pain site) where attention was less focused, suggesting that analgesic effect of placebo electroacupuncture mainly rely on the motivation of its spatial-specific placebo responses via attention mechanism. This inference can be further supported by the evidence that the significant interaction effect of manipulation laterality and treatment was exclusively located within the default mode network, including the bilateral superior parietal lobule, inferior parietal lobule, precuneus, and left posterior cingulate cortex. It is also proved that disruptions of the default mode network may account for the cognitive and behavioral impairments in chronic pain patients. Our findings further suggested that default mode network participates in the modulation of spatial-oriented attention on placebo analgesia as a mechanism underlying the degree to which treatment side corresponding to the pain.
关键词Interaction Effect Laterality Electroacupuncture Capsaicin Pain Model Default Mode Network Placebo Analgesia
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1177/1744806916683684
关键词[WOS]PLACEBO ANALGESIA ; PAIN ; ACTIVATION ; BRAIN ; DISSOCIATION ; EXPECTATIONS ; STIMULATION ; EXPECTANCY ; MECHANISMS ; EXPERIENCE
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81371630 ; Shaanxi Nova program ; Fundamental Research Funds for the Central Universities ; National key research and development plan of China(2016YFC0100300) ; 81571752 ; 81227901 ; 81571640 ; 81371530)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000412446600001
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20729
专题中国科学院分子影像重点实验室
作者单位1.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Dept Biomed Engn, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
2.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Med Imaging, Xian, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
5.Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Niu, Xuan,Zhang, Ming,Liu, Zhenyu,et al. Interaction of acupuncture treatment and manipulation laterality modulated by the default mode network[J]. MOLECULAR PAIN,2016,13.
APA Niu, Xuan.,Zhang, Ming.,Liu, Zhenyu.,Bai, Lijun.,Sun, Chuanzhu.,...&Tian, Jie.(2016).Interaction of acupuncture treatment and manipulation laterality modulated by the default mode network.MOLECULAR PAIN,13.
MLA Niu, Xuan,et al."Interaction of acupuncture treatment and manipulation laterality modulated by the default mode network".MOLECULAR PAIN 13(2016).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Niu, Xuan]的文章
[Zhang, Ming]的文章
[Liu, Zhenyu]的文章
百度学术
百度学术中相似的文章
[Niu, Xuan]的文章
[Zhang, Ming]的文章
[Liu, Zhenyu]的文章
必应学术
必应学术中相似的文章
[Niu, Xuan]的文章
[Zhang, Ming]的文章
[Liu, Zhenyu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。