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Interaction of acupuncture treatment and manipulation laterality modulated by the default mode network
Niu, Xuan1,2; Zhang, Ming2; Liu, Zhenyu3; Bai, Lijun1,4; Sun, Chuanzhu1; Wang, Shan1; Wang, Xiaocui1; Chen, Zhen1; Chen, Hongyan5; Tian, Jie3
Source PublicationMOLECULAR PAIN
AbstractAppropriate selection of ipsilateral or contralateral electroacupuncture (corresponding to the pain site) plays an important role in reaching its better curative effect; however, the involving brain mechanism still remains unclear. Compared with the heat pain model generally established in previous study, capsaicin pain model induces reversible cutaneous allodynia and is proved to be better simulating aspects of clinical nociceptive and neuropathic pain. In the current study, 24 subjects were randomly divided into two groups with a 2 x 2 factorial design: laterality (ipsi- or contralateral side, inter-subject) x treatment with counter-balanced at an interval of one week (verum and placebo electroacupuncture, within-subject). We observed subjective pain intensity and brain activations changes induced by capsaicin allodynia pain stimuli before and after electroacupuncture treatment at acupoint LI4 for 30 min. Analysis of variance results indicated that ipsilateral electroacupuncture treatment produced significant pain relief and wide brain signal suppressions in pain-related brain areas compared with contralateral electroacupuncture. We also found that verum electroacupuncture at either ipsi- or contralateral side to the pain site exhibited comparable significant magnitudes of analgesic effect. By contrast, placebo electroacupuncture elicited significant pain reductions only on the ipsilateral rather than contralateral side. It was inferred that placebo analgesia maybe attenuated on the region of the body (opposite to pain site) where attention was less focused, suggesting that analgesic effect of placebo electroacupuncture mainly rely on the motivation of its spatial-specific placebo responses via attention mechanism. This inference can be further supported by the evidence that the significant interaction effect of manipulation laterality and treatment was exclusively located within the default mode network, including the bilateral superior parietal lobule, inferior parietal lobule, precuneus, and left posterior cingulate cortex. It is also proved that disruptions of the default mode network may account for the cognitive and behavioral impairments in chronic pain patients. Our findings further suggested that default mode network participates in the modulation of spatial-oriented attention on placebo analgesia as a mechanism underlying the degree to which treatment side corresponding to the pain.
KeywordInteraction Effect Laterality Electroacupuncture Capsaicin Pain Model Default Mode Network Placebo Analgesia
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(81371630 ; Shaanxi Nova program ; Fundamental Research Funds for the Central Universities ; National key research and development plan of China(2016YFC0100300) ; 81571752 ; 81227901 ; 81571640 ; 81371530)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000412446600001
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Dept Biomed Engn, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
2.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Med Imaging, Xian, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
5.Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Niu, Xuan,Zhang, Ming,Liu, Zhenyu,et al. Interaction of acupuncture treatment and manipulation laterality modulated by the default mode network[J]. MOLECULAR PAIN,2016,13.
APA Niu, Xuan.,Zhang, Ming.,Liu, Zhenyu.,Bai, Lijun.,Sun, Chuanzhu.,...&Tian, Jie.(2016).Interaction of acupuncture treatment and manipulation laterality modulated by the default mode network.MOLECULAR PAIN,13.
MLA Niu, Xuan,et al."Interaction of acupuncture treatment and manipulation laterality modulated by the default mode network".MOLECULAR PAIN 13(2016).
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