CASIA OpenIR  > 中国科学院分子影像重点实验室
Alterations in regional homogeneity of resting-state cerebral activity in patients with chronic prostatitis/chronic pelvic pain syndrome
Lin, Yusong1,2; Bai, Yan3,4,5,6; Liu, Peng7; Yang, Xuejuan7; Qin, Wei7; Gu, Jianqin4,8; Ding, Degang4,9; Tian, Jie10; Wang, Meiyun3,4,5,6,8
Source PublicationPLOS ONE
2017-09-19
Volume12Issue:9
SubtypeArticle
AbstractThe purpose of this study was to explore the neural mechanism in Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) using resting-state functional magnetic resonance imaging. The functional magnetic resonance imaging was performed on 31 male CP/CPPS-patients and 31 age and education matched male healthy controls on a 3-T magnetic resonance imaging unit. A two-sample t-test was adopted to reveal the regional homogeneity between the patients and healthy controls. The mean regional homogeneity values in the alerted brain regions of patients were correlated with the clinical measurements by using Pearson's correlation analyses. The CP/CPPS-patients had significantly decreased regional homogeneity in the bilateral anterior cingulate cortices, insular cortices and right medial prefrontal cortex, while significantly increased regional homogeneity in the brainstem and right thalamus compared with the healthy controls. In the CP/CPPSpatients, the mean regional homogeneity value in the left anterior cingulate cortex, bilateral insular cortices and brainstem were respectively correlated with the National Institutes of Health Chronic Prostatitis Symptom Index total score and pain subscale. These brain regions are important in the pain modulation process. Therefore, an impaired pain modulatory system, either by decreased descending pain inhibition or enhanced pain facilitation, may explain the pain symptoms in CP/CPPS.
WOS HeadingsScience & Technology
DOI10.1371/journal.pone.0184896
WOS KeywordOPIOID RECEPTOR AVAILABILITY ; ANTERIOR CINGULATE CORTEX ; NATIONAL-INSTITUTES ; SYMPTOM INDEX ; BACK-PAIN ; FIBROMYALGIA ; FMRI ; HEALTH ; UNPLEASANTNESS ; ACTIVATION
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31470047 ; Henan Province Scientific and Technological Innovation Talents Project(164200510014) ; Henan Province Scientific and Technological Cooperation Project(152106000014) ; Key Project of Henan Medical Science and Technology Project(201501011) ; 81641168 ; 81271565 ; 81601466 ; 81271644 ; 81471811)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000411166600050
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20734
Collection中国科学院分子影像重点实验室
Affiliation1.Zhengzhou Univ, Cooperat Innovat Ctr Internet Healthcare, Zhengzhou, Henan, Peoples R China
2.Zhengzhou Univ, Sch Software & Appl Technol, Zhengzhou, Henan, Peoples R China
3.Zhengzhou Univ, Peoples Hosp, Dept Radiol, Zhengzhou, Henan, Peoples R China
4.Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China
5.Henan Key Lab Med Imaging Neurol Dis, Xinjiang, Peoples R China
6.Henan Univ, Med Sch, Zhengzhou, Henan, Peoples R China
7.Xidian Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China
8.Zhengzhou Univ, Peoples Hosp, Henan Prov Clin Big Data Anal & Serv Engn Res Ctr, Zhengzhou, Henan, Peoples R China
9.Zhengzhou Univ, Peoples Hosp, Dept Urol, Zhengzhou, Henan, Peoples R China
10.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Lin, Yusong,Bai, Yan,Liu, Peng,et al. Alterations in regional homogeneity of resting-state cerebral activity in patients with chronic prostatitis/chronic pelvic pain syndrome[J]. PLOS ONE,2017,12(9).
APA Lin, Yusong.,Bai, Yan.,Liu, Peng.,Yang, Xuejuan.,Qin, Wei.,...&Wang, Meiyun.(2017).Alterations in regional homogeneity of resting-state cerebral activity in patients with chronic prostatitis/chronic pelvic pain syndrome.PLOS ONE,12(9).
MLA Lin, Yusong,et al."Alterations in regional homogeneity of resting-state cerebral activity in patients with chronic prostatitis/chronic pelvic pain syndrome".PLOS ONE 12.9(2017).
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