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Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders
Xiao, Xiao1; Wang, Lu1; Wang, Chuang2; Yuan, Ti-Fei3; Zhou, Dongsheng4; Zheng, Fanfan5; Li, Lingyi1; Grigoroiu-Serbanescu, Maria6; Ikeda, Masashi7; Iwata, Nakao7; Takahashi, Atsushi8,9; Kamatani, Yoichiro8; Kubo, Michiaki10; Preisig, Martin11; Kutalik, Zoltan12,13; Castelao, Enrique11; Pistis, Giorgio11; Amin, Najaf14; van Duijn, Cornelia M.14; Forstner, Andreas J.15,16,17,18,19; Strohmaier, Jana20; Hecker, Julian15,21; Schulze, Thomas G.22; Mueller-Myhsok, Bertram23,24,25; Reif, Andreas26; Mitchell, Philip B.27,28; Martin, Nicholas G.29; Schofield, Peter R.30,31; Cichon, Sven15,16,17,19,32; Noethen, Markus M.15,16; Chang, Hong1; Luo, Xiong-Jian1; Fang, Yiru33; Yao, Yong-Gang1,34; Zhang, Chen33; Rietschel, Marcella; Li, Ming1,34; Adv Collaborative Study Mood Dis; MooDS Bipolar Consortium
2017-12-11
发表期刊TRANSLATIONAL PSYCHIATRY
卷号7
文章类型Article
摘要Bipolar disorder (BPD) and major depressive disorder (MDD) are primary major mood disorders. Recent studies suggest that they share certain psychopathological features and common risk genes, but unraveling the full genetic architecture underlying the risk of major mood disorders remains an important scientific task. The public genome-wide association study (GWAS) data sets offer the opportunity to examine this topic by utilizing large amounts of combined genetic data, which should ultimately allow a better understanding of the onset and development of these illnesses. Genome-wide meta-analysis was performed by combining two GWAS data sets on BPD and MDD (19,637 cases and 18,083 controls), followed by replication analyses for the loci of interest in independent 12,364 cases and 76,633 controls from additional samples that were not included in the two GWAS data sets. The single-nucleotide polymorphism (SNP) rs10791889 at 11q13.2 was significant in both discovery and replication samples. When combining all samples, this SNP and multiple other SNPs at 2q11.2 (rs717454), 8q21.3 (rs10103191), and 11q13.2 (rs2167457) exhibited genome-wide significant association with major mood disorders. The SNPs in 2q11.2 and 8q21.3 were novel risk SNPs that were not previously reported, and SNPs at 11q13.2 were in high LD with potential BPD risk SNPs implicated in a previous GWAS. The genome-wide significant loci at 2q11.2 and 11q13.2 exhibited strong effects on the mRNA expression of certain nearby genes in cerebellum. In conclusion, we have identified several novel loci associated with major mood disorders, adding further support for shared genetic risk between BPD and MDD. Our study highlights the necessity and importance of mining public data sets to explore risk genes for complex diseases such as mood disorders.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1038/s41398-017-0019-0
关键词[WOS]GENOME-WIDE ASSOCIATION ; BIPOLAR DISORDER ; DEPRESSIVE DISORDER ; GENE-EXPRESSION ; HIPPOCAMPAL STRUCTURE ; EUROPEAN POPULATIONS ; ALLELIC DIFFERENCES ; CONFERS RISK ; HAN CHINESE ; SUSCEPTIBILITY
收录类别SCI
语种英语
项目资助者Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13000000) ; CAS Pioneer Hundred Talents Program ; German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the the e:Med Programme(01ZX1314A ; German Research Foundation (DFG)(FOR2107 ; UEFISCDI, Bucharest, Romania(89/2012) ; German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent(01ZX1314A) ; Australian National Health ; Medical Research Council(GNT1037196) ; European Commission FP6 STRP grant(018947 (LSHG-CT-2006-01947)) ; European Community's Seventh Framework Programme (FP7) by the European Commission under the programme "Quality of Life and Management of the Living Resources" of 5th Framework Programme(HEALTH-F4-2007-201413 ; Netherlands Organization for Scientific Research ; Russian Foundation for Basic Research(NWO-RFBR 047.017.043) ; ZonMw grant(91111025) ; Hersenstichting Nederland(F2013(1)-28) ; 01ZX1314G) ; 11-1 ; QLG2-CT-2002-01254) ; NO246/10-1)
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000419040900001
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20757
专题脑网络组研究中心
作者单位1.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China
2.Ningbo Univ, Sch Med, Prov Key Lab Pathophysiol, Dept Pharmacol, Ningbo, Zhejiang, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
4.Ningbo Kangning Hosp, Ningbo, Zhejiang, Peoples R China
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
6.Alexandru Obregia Clin Psychiat Hosp, Biometr Psychiat Genet Res Unit, Bucharest, Romania
7.Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi, Japan
8.RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan
9.Natl Cerebral & Cardiovasc Ctr, Omics Res Ctr, Lab Omics Informat, Osaka, Japan
10.RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
11.CHU Vaudois, Dept Psychiat, Prilly, Switzerland
12.CHU Vaudois, Inst Social & Prevent Med, Lausanne, Switzerland
13.Swiss Inst Bioinformat, Lausanne, Switzerland
14.Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
15.Univ Bonn, Inst Human Genet, Bonn, Germany
16.Univ Bonn, Life & Brain Ctr, Dept Gen, Bonn, Germany
17.Univ Basel, Dept Biomed, Human Genom Res Grp, Basel, Switzerland
18.Univ Basel, Dept Psychiat UPK, Basel, Switzerland
19.Univ Basel Hosp, Inst Med Genet & Pathol, Basel, Switzerland
20.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol, Mannheim, Germany
21.Univ Bonn, Inst Genom Math, Bonn, Germany
22.Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Gen, Munich, Germany
23.Max Planck Inst Psychiat, Munich, Germany
24.Munich Cluster Syst Neurol SyNergy, Munich, Germany
25.Univ Liverpool, Inst Translat Med, Liverpool, Merseyside, England
26.Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany
27.Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia
28.Black Dog Inst, Sydney, NSW, Australia
29.QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
30.Neurosci Res Australia, Sydney, NSW, Australia
31.Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
32.Res Ctr Julich, Struct & Funct Org Brain Genom Imaging, Inst Neurosci & Med INM 1, Julich, Germany
33.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai, Peoples R China
34.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China
推荐引用方式
GB/T 7714
Xiao, Xiao,Wang, Lu,Wang, Chuang,et al. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders[J]. TRANSLATIONAL PSYCHIATRY,2017,7.
APA Xiao, Xiao.,Wang, Lu.,Wang, Chuang.,Yuan, Ti-Fei.,Zhou, Dongsheng.,...&MooDS Bipolar Consortium.(2017).Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.TRANSLATIONAL PSYCHIATRY,7.
MLA Xiao, Xiao,et al."Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders".TRANSLATIONAL PSYCHIATRY 7(2017).
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