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MicroRNA132 associated multimodal neuroimaging patterns in unmedicated major depressive disorder
Qi, Shile1,2,3; Yang, Xiao4,5,6; Zhao, Liansheng4,5,6; Calhoun, Vince D.7,8,9,10; Perrone-Bizzozero, Nora9,10; Liu, Shengfeng1,2; Jiang, Rongtao1,2,3; Jiang, Tianzi1,2,3,11; Sui, Jing1,2,3,7,8,11; Ma, Xiaohong4,5,6
2018-03-01
发表期刊BRAIN
卷号141期号:3页码:916-926
文章类型Article
摘要There is compelling evidence that epigenetic factors contribute to the manifestation of depression, in which microRNA132 (miR-132) is suggested to play a pivotal role in the pathogenesis and neuronal mechanisms underlying the symptoms of depression. Additionally, several depression-associated genes [MECP2, ARHGAP32 (p250GAP), CREB, and period genes] were experimentally validated as miR-132 targets. However, most studies regarding miR-132 in major depressive disorder are based on post-mortem, animal models or genetic comparisons. This work will be the first attempt to investigate how miR-132 dysregulation may impact covariation of multimodal brain imaging data in 81 unmedicated major depressive patients and 123 demographically-matched healthy controls, as well as in a medication-naive subset of major depressive patients. MiR-132 values in blood (patients4controls) was used as a prior reference to guide fusion of three MRI features: fractional amplitude of low frequency fluctuations, grey matter volume, and fractional anisotropy. The multimodal components correlated with miR-132 also show significant group difference in loadings. Results indicate that (i) higher miR-132 levels in major depressive disorder are associated with both lower fractional amplitude of low frequency fluctuations and lower grey matter volume in fronto-limbic network; and (ii) the identified brain regions linked with increased miR-132 levels were also associated with poorer cognitive performance in attention and executive function. Using a data-driven, supervised-learning method, we determined that miR-132 dysregulation in major depressive disorder is associated with multi-facets of brain function and structure in fronto-limbic network (the key network for emotional regulation and memory), which deepens our understanding of how miR-132 dysregulation in major depressive disorders contribute to the loss of specific brain areas and is linked to relevant cognitive impairments.
关键词Major Depressive Disorder Microrna132 Supervised Multimodal Fusion Fronto-limbic Network Unmedicated
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1093/brain/awx366
关键词[WOS]VOXEL-BASED MORPHOMETRY ; MOOD DISORDERS ; SCHIZOPHRENIA ; AMYGDALA ; METAANALYSIS ; PLASTICITY ; VOLUME ; ABNORMALITIES ; CONNECTIVITY ; HIPPOCAMPUS
收录类别SCI ; SSCI
语种英语
项目资助者National High-Tech Development Program (863 plan)(2015AA020513) ; '100 Talents Plan' of Chinese Academy of Sciences ; Chinese National Natural Science Foundation(81471367 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02060005) ; National Science and Technology Support plan(2015BAI13B02) ; NIH(R01EB005846 ; 81671344 ; 1R01MH094524 ; 61773380) ; P20GM103472)
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology ; Neurosciences
WOS记录号WOS:000426813600033
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20782
专题脑网络组研究中心
通讯作者Sui, Jing
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Sichuan Univ, West China Hosp, Psychiat Lab, Chengdu, Sichuan, Peoples R China
5.Sichuan Univ, State Key Lab Biotherapy, Mental Hlth Ctr, West China Hosp, Chengdu, Sichuan, Peoples R China
6.Sichuan Univ, West China Hosp, Huaxi Brain Res Ctr, Chengdu, Sichuan, Peoples R China
7.Mind Res Network, Albuquerque, NM USA
8.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA
9.Univ New Mexico, Dept Neurosci & Psychiat, Albuquerque, NM 87131 USA
10.Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
11.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China
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Qi, Shile,Yang, Xiao,Zhao, Liansheng,et al. MicroRNA132 associated multimodal neuroimaging patterns in unmedicated major depressive disorder[J]. BRAIN,2018,141(3):916-926.
APA Qi, Shile.,Yang, Xiao.,Zhao, Liansheng.,Calhoun, Vince D..,Perrone-Bizzozero, Nora.,...&Ma, Xiaohong.(2018).MicroRNA132 associated multimodal neuroimaging patterns in unmedicated major depressive disorder.BRAIN,141(3),916-926.
MLA Qi, Shile,et al."MicroRNA132 associated multimodal neuroimaging patterns in unmedicated major depressive disorder".BRAIN 141.3(2018):916-926.
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