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Resting fMRI Measures Are Associated with Assessed by the MATRICS Consensus Cognitive Battery Cognitive Deficits in Schizophrenia
Hao He; Bustillo Juan R; Yuhui Du; Qingbao Yu.; Jones Thomas R; Tianzi Jiang; Vince D Calhoun; Sui Jing(隋婧)
Conference NameSPIE Medical Imaging Conference 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
Conference Date2015/2/22-26
Conference PlaceOrlando, USA
AbstractThe cognitive deficits of schizophrenia are largely resistant to current treatment, and are thus a life-long burden to patients. The MATRICS consensus cognitive battery (MCCB) provides a reliable and valid assessment of cognition across a comprehensive set of cognitive domains for schizophrenia. In resting-state fMRI, functional connectivity associated with MCCB has not yet been examined. In this paper, the interrelationships between MCCB and the abnormalities seen in two types of functional measures from resting-state fMRI-fractional amplitude of low frequency fluctuations (fALFF) and functional network connectivity (FNC) maps were investigated in data from 47 schizophrenia patients and 50 age-matched healthy controls. First, the fALFF maps were generated and decomposed by independent component analysis (ICA), and then the component showing the highest correlation with MCCB composite scores was selected. Second, the whole brain was separated into functional networks by group ICA, and the FNC maps were calculated. The FNC strengths with most significant correlations with MCCB were displayed and spatially overlapped with the fALFF component of interest. It demonstrated increased cognitive performance associated with higher fALFF values (intensity of regional spontaneous brain activity) in prefrontal regions, inferior parietal lobe (IPL) but lower ALFF values in thalamus, striatum, and superior temporal gyrus (STG). Interestingly, the FNC showing significant correlations with MCCB were in well agreement with the activated regions with highest z-values in fALFF component. Our results support the view that functional deficits in distributed cortico-striato-thalamic circuits and inferior parietal lobe may account for several aspects of cognitive impairment in schizophrenia.
KeywordResting Fmri Cognitive Battery Cognitive Deficits Schizophrenia
Document Type会议论文
AffiliationInstitute of Automation Chinese Academy of Sciences
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hao He,Bustillo Juan R,Yuhui Du,et al. Resting fMRI Measures Are Associated with Assessed by the MATRICS Consensus Cognitive Battery Cognitive Deficits in Schizophrenia[C],2015.
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