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Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe
Jin, Yushen1,3; Wang, Kun1,3; Tian, Jie1,2,3,4
2018-04-01
发表期刊BIOCONJUGATE CHEMISTRY
卷号29期号:4页码:1475-1484
文章类型Article
摘要In dinical imaging modalities, MRI is suitable for preoperative examination. Fluorescence imaging has been proposed to improve the detectability of cancer lesions during the operation. However, the specificity and accuracy of the two imaging modalities is limited. To improve the prognosis and survival rate of the patient suffering from hepatocellular carcinoma (HCC), it is very important to develop a specific probe to achieve early detection and precise resection of HCC. We selected HCC targeting peptide SP94 to conjugate with a NIR dye and Gd chelated DOTA to enhance the specificity of different imaging modalities. MRI and fluorescence imaging were used for preoperative examination of the cancer and detecting the tumor in the operation, respectively. MRI and fluorescence signals significantly increased when HCC occurs and the obtained probe shows high uptake in HCC but negligible uptake in the normal liver tissues. The signal-to-background ratio is higher than 2.23 (MRI) and 2.0 (fluorescence imaging) with noninvasive imaging modalities. After the intraperitoneal cavity was surgically exposed, the signal-to-background ratio is higher than 4.6. By combining the high specificity of our probe with the high sensitivity of fluorescence imaging, the microprimary malignancy and micrometastasis foci (diameter <1 mm) can be easily detected after the intraperitoneal cavity is exposed. These results indicated that our probe is conductive to the early detection and precise resection of the HCC and has the potential to improve the diagnosis and treatment of patients with HCC.
关键词Fluorescence Imaging Mri Hepatocellular Carcinoma Sp94 Peptide Imaging-guided Surgery
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1021/acs.bioconjchem.8b00161
关键词[WOS]CLINICAL-APPLICATIONS ; OVARIAN-CANCER ; QUANTUM DOTS ; LIVER ; DELIVERY ; DIAGNOSIS ; NANOPARTICLES ; METASTASES ; THERAPY ; SURGERY
收录类别SCI
语种英语
项目资助者National Key Research and Development Program of China(2017YFA0205200 ; National Natural Science Foundation of China(81701771 ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 2015CB755500 ; 81227901 ; 2016YFA0201401) ; 81527805 ; 61231004)
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
WOS记录号WOS:000430641700070
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21692
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
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Jin, Yushen,Wang, Kun,Tian, Jie. Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe[J]. BIOCONJUGATE CHEMISTRY,2018,29(4):1475-1484.
APA Jin, Yushen,Wang, Kun,&Tian, Jie.(2018).Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe.BIOCONJUGATE CHEMISTRY,29(4),1475-1484.
MLA Jin, Yushen,et al."Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe".BIOCONJUGATE CHEMISTRY 29.4(2018):1475-1484.
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