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Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma
Jin, Yushen1,2; Yang, Xin1,2; Tian, Jie1,2,3,4
2018-05-28
发表期刊NANOSCALE
卷号10期号:20页码:9594-9601
文章类型Article
摘要Early identification and treatment of hepatocellular carcinoma is very important for improving the prognosis and survival rate of the patient. To enhance the visualization and treatment efficiency of HCC, a theranostic agent has been developed that combines photoacoustic/fluorescence imaging with photothermal therapy for cancer. We report the synthesis of multifunctional theranostic SP94-modified polypyrrole (PPy)-BSA-ICG nanoparticles by a simple method. The multifunctional theranostic agent helped to combine two modes of imaging modalities, i.e. photoacoustic and near infrared (NIR) fluorescence imaging, together with photothermal therapy. These nanoparticles exhibited an excellent stability in physiological solutions (PBS, pH 7.4 at 37 degrees C), a higher tumor accumulation as compared to the unmodified nanoparticles, and minimal nonspecific uptake by other normal organs such as liver and spleen. Most importantly, the nanoparticles could effectively kill the tumor through photothermal therapy with no tumor recurrence upon a single laser irradiation event. These results indicate that SP94-modified PPy-BSA-ICG is potentially a promising theranostic agent for image-guided cancer therapy as it overcomes the limitations of each of the imaging modalities and thus improves the therapeutic efficiency and reduces the side effects.
关键词Polypyrrole Nanoparticles Photoacoustic And Near Infrared (Nir) Fluorescence Imaging Sp94 Peptide Hepatocellular Carcinoma Image-guided Photothermal Therapy
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1039/c8nr02036a
关键词[WOS]GUIDED-PHOTOTHERMAL THERAPY ; THERANOSTIC AGENT ; INDOCYANINE GREEN ; GOLD NANOCAGES ; PRUSSIAN BLUE ; CUS NANOPARTICLES ; TANTALUM OXIDE ; DUAL-MODALITY ; CANCER ; FLUORESCENCE
收录类别SCI
语种英语
项目资助者National Key Research and Development Program of China(2017YFA0205200 ; National Natural Science Foundation of China(81227901 ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 2015CB755500 ; 81527805 ; 2016YFA0201401) ; 81701771 ; 61231004)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000433260300019
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21693
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100080, Peoples R China
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Jin, Yushen,Yang, Xin,Tian, Jie. Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma[J]. NANOSCALE,2018,10(20):9594-9601.
APA Jin, Yushen,Yang, Xin,&Tian, Jie.(2018).Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma.NANOSCALE,10(20),9594-9601.
MLA Jin, Yushen,et al."Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma".NANOSCALE 10.20(2018):9594-9601.
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