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Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd
Ma, Xibo1; Jin, Yushen1; Wang, Yi1,2; Zhang, Shuai1,3; Peng, Dong1; Yang, Xin1; Wei, Shoushui3; Chai, Wei2; Li, Xuejun4; Tian, Jie1
2018
发表期刊CONTRAST MEDIA & MOLECULAR IMAGING
期号2018页码:9321862
文章类型Article
摘要Tumor cell complete extinction is a crucial measure to evaluate antitumor efficacy. The difficulties in defining tumor margins and finding satellite metastases are the reason for tumor recurrence. A synergistic method based on multimodality molecular imaging needs to be developed so as to achieve the complete extinction of the tumor cells. In this study, graphene oxide conjugated with gold nanostars and chelated with Gd through 1,4,7,10-tetraazacyclododecane-N, N', N, N'-tetraacetic acid (DOTA) (GO-AuNS-DOTA-Gd) were prepared to target HCC-LM3-fLuc cells and used for therapy. For subcutaneous tumor, multimodality molecular imaging including photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) and the related processing techniques were used to monitor the pharmacokinetics process of GO-AuNS-DOTA-Gd in order to determine the optimal time for treatment. For orthotopic tumor, MRI was used to delineate the tumor location and margin in vivo before treatment. Then handheld photoacoustic imaging system was used to determine the tumor location during the surgery and guided the photothermal therapy. The experiment result based on orthotopic tumor demonstrated that this synergistic method could effectively reduce tumor residual and satellite metastases by 85.71% compared with the routine photothermal method without handheld PAI guidance. These results indicate that this multimodality molecular imaging-guided photothermal therapy method is promising with a good prospect in clinical application.
关键词Multimodality Molecular Imaging Tumor Border Delineation Photothermal Therapy Hepatocellular Carcinoma
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1155/2018/9321862
关键词[WOS]IN-VIVO ; HEPATOCELLULAR-CARCINOMA ; CANCER ; TOMOGRAPHY ; SYSTEM
收录类别SCI
语种英语
项目资助者National Key Research Program of China(2016YFA0100900 ; National Natural Science Foundation of China(81227901 ; Key Research Program of the Chinese Academy of Sciences(KGZD-EW-T03) ; Scientific Research and Equipment Development Project of Chinese Academy of Sciences(YZ201457) ; Beijing Natural Science Foundation(7174314) ; 2016YFA0100902) ; 815270805 ; 61231004 ; 81471739 ; 81472594 ; 81770781)
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
WOS类目Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000432965400001
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21694
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
3.Shandong Univ, Sch Control Sci & Engn, Inst Biomed Engn, Jinan 250061, Shandong, Peoples R China
4.Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China
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Ma, Xibo,Jin, Yushen,Wang, Yi,et al. Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd[J]. CONTRAST MEDIA & MOLECULAR IMAGING,2018(2018):9321862.
APA Ma, Xibo.,Jin, Yushen.,Wang, Yi.,Zhang, Shuai.,Peng, Dong.,...&Tian, Jie.(2018).Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd.CONTRAST MEDIA & MOLECULAR IMAGING(2018),9321862.
MLA Ma, Xibo,et al."Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd".CONTRAST MEDIA & MOLECULAR IMAGING .2018(2018):9321862.
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