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A novel plectin/integrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer
Wang Qian1,2,3; Yan Hao2,3,4; Jin YS(靳玉慎)2; Wang Zihua4; Huang Wenhui2; Qiu Jia2; Kang Feiyu3; Wang Kun2; Zhao Xinming1; Tian Jie2
2018-08-26
发表期刊Biomaterials
期号183页码:173-184
摘要Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies with poor patient outcomes often resulting from delayed diagnosis. Therefore, early diagnosis can lead to a better prognosis and improved outcomes. In this study, we have developed a novel conjugate complex of plectin/integrin-targeted bispecific molecular probe, termed Gd-Cy7-PTP/RGD, to be used for magnetic resonance/near-infrared imaging (MRI/NIRF) of pancreatic cancer in vivo. This bispecific molecular probe comprises four parts: Gd(III) for MRI, cyanine 7 (Cy7) for NIRF, the peptide PTP for binding to plectin-1 specifically overexpressed on the surface of PDAC cells, and the peptide RGD for targeting integrin widely expressed on pancreatic duct epithelial cells and angiogenesis. Remarkably, the combination of PTP and RGD greatly increased the targeting efficiency in vitro and in vivocompared to that of either single peptide. Moreover, such bispecific molecular probes target pancreatic neoplasms and angiogenesis simultaneously, producing a “multi-level” targeting effect confirmed by immunofluorescence testing in vitro and in vivo. Under the guidance of MRI/NIRF dual-modality imaging, NIRF-guided delineation of surgical margins during operations was successfully achieved in orthotopic pancreatic cancer. This study promotes further exploration of bispecific molecular probes for clinical application.
关键词Bispecific Peptides Early Diagnosis Molecular Imaging Pancreatic Cancer Theranostics
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21695
专题中国科学院分子影像重点实验室
作者单位1.Department of Imaging Diagnosis National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China
2.CAS Key Laboratory of Molecular Imaging, Institute of Automation Chinese Academy of Sciences, Beijing, 100190, China
3.School of Materials Science and Engineering, Graduate School at Shenzhen, Tsinghua University, Beijing, 100190, China
4.Key Laboratory of Colloid Interface and Chemical Thermodynamics, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, China
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GB/T 7714
Wang Qian,Yan Hao,Jin YS,et al. A novel plectin/integrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer[J]. Biomaterials,2018(183):173-184.
APA Wang Qian.,Yan Hao.,Jin YS.,Wang Zihua.,Huang Wenhui.,...&Tian Jie.(2018).A novel plectin/integrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer.Biomaterials(183),173-184.
MLA Wang Qian,et al."A novel plectin/integrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer".Biomaterials .183(2018):173-184.
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