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Microwave-Triggered Smart Drug Release from Liposomes Co-Encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer
Jin YS(靳玉慎); Liang Xiaolong; An Yunkun; Dai Zhifei
Source PublicationBioconjugate Chemistry
2016
Issue27Pages:2931-2942
AbstractThe microwave and temperature sensitive liposomes were fabricated successfully from 1,2-dipalmityol-sn-glycero-3-phosphocholine (DPPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (DSPE-PEG2000) with a molar ratio of 4:1:0.26 by co-encapsulating NaCl and doxorubicin (DOX) through the thin-film hydration method to externally manipulate drug release at a predetermined location in the body at a desired time in the right dosage for combination microwave hyperthermia and chemotherapy of cancer to afford a synergistic therapeutic effect. It was found that the confinement of the high concentration of NaCl ions inside the small size of the liposomes led to a more-rapid temperature elevation than the dissociative ions upon microwave treatment. More than 67.6% doxorubicinwas released from the DOX and NaCl co-loaded liposomes (DOX&NaCl@liposomes) upon microwave irradiation for 2 min. After incubation with 2 mg/mL DOX&NaCl@liposomes for 4 h followed by treatment with microwave for 2 min, the inhibition rate of human breast cancer cell MDA-MB-231 was evaluated as 76.1%, much higher than that for NaCl@liposomes (29.8%) and DOX@liposomes (40.2%). The tumor growth inhibition was evaluated to be 73.4% after intravenous injection of DOX&NaCl@liposomes followed by microwave irradiation, much higher than that with only NaCl@liposomes (41.5%) or DOX@liposomes (45.5%) combined with microwave irradiation. Therefore, DOX&NaCl@liposomes could serve as a promising thermochemotherapy nanomedicine for cancer treatment because of its excellent microwavesusceptible property and good biocompatibility.
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Indexed BySCI
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21712
Collection中国科学院分子影像重点实验室
Recommended Citation
GB/T 7714
Jin YS,Liang Xiaolong,An Yunkun,et al. Microwave-Triggered Smart Drug Release from Liposomes Co-Encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer[J]. Bioconjugate Chemistry,2016(27):2931-2942.
APA Jin YS,Liang Xiaolong,An Yunkun,&Dai Zhifei.(2016).Microwave-Triggered Smart Drug Release from Liposomes Co-Encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer.Bioconjugate Chemistry(27),2931-2942.
MLA Jin YS,et al."Microwave-Triggered Smart Drug Release from Liposomes Co-Encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer".Bioconjugate Chemistry .27(2016):2931-2942.
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