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Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury.
Xiaohua Jia
2012-09-10
发表期刊BMC Nephrology
卷号13期号:0页码:105
摘要
; Background: Bone marrow (BM) stem cells have been reported to contribute to tissue repair after kidney injury
model. However, there is no direct evidence so far that BM cells can trans-differentiate into renal stem cells.

Methods: To investigate whether BM stem cells contribute to repopulate the renal stem cell pool, we transplanted
BM cells from transgenic mice, expressing enhanced green fluorescent protein (EGFP) into wild-type irradiated
recipients. Following hematological reconstitution and ischemia-reperfusion (I/R), Sca-1 and c-Kit positive renal stem
cells in kidney were evaluated by immunostaining and flow cytometry analysis. Moreover, granulocyte colony
stimulating factor (G-CSF) was administrated to further explore if G-CSF can mobilize BM cells and enhance transdifferentiation efficiency of BM cells into renal stem cells.

Results: BM-derived cells can contribute to the Sca-1+ or c-Kit+ renal progenitor cells population, although most
renal stem cells came from indigenous cells. Furthermore, G-CSF administration nearly doubled the frequency of
Sca-1+ BM-derived renal stem cells and increased capillary density of I/R injured kidneys.

Conclusions: These findings indicate that BM derived stem cells can give rise to cells that share properties of renal
resident stem cell. Moreover, G-CSF mobilization can enhance this effect.


关键词Bone Marrow Transplantation
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21791
专题中国科学院分子影像重点实验室
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Xiaohua Jia. Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury.[J]. BMC Nephrology,2012,13(0):105.
APA Xiaohua Jia.(2012).Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury..BMC Nephrology,13(0),105.
MLA Xiaohua Jia."Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury.".BMC Nephrology 13.0(2012):105.
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