CASIA OpenIR  > 中国科学院分子影像重点实验室
Cerasomal doxorubicin with long-term storage stability and controllable sustained release
Jin Yushen; Yue Xiuli; Wu Xiaoyi; Cao Zhong; Dai Zhifei
2012-05-30
发表期刊Acta Biomaterialia
期号8页码:3372-3380
摘要Liposomal nanohybrid cerasomes display a remarkable ability to maintain their size and retain encapsulated doxorubicin (DOX) over a period of 90 days under storage conditions in solution compared with liposomes and liposils. Cerasomes retained 92.1 ± 2.9% of the drug payload after 90 days storage, much more than liposomes (35.2 ± 2.5%) and liposils (53.2 ± 5.5%). Under physiologically relevant conditions cerasomes exhibit a low initial burst in the first 5 h and subsequent sustained release of DOX over the next 150 h. Moreover, the magnitude of the initial burst and the rate of sustained release of DOX from cerasomes can be modulated by incorporating dipalmitoylphosphatidylglycerol (DPPG) in the cerasome structure and altering the ratios of the cerasome-forming lipid and phospholipids. Consequently, a wide
range of release profiles can be achieved by altering the vesicle composition. Finally, human ovarian cancer cells are effectively killed by DOX released from cerasomes. Together these results suggest that cerasomes may be a promising drug delivery system for the long-term storage and controllable sustained release of the anticancer drug DOX.

 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
关键词Cerasome Doxorubicin Controlled Release Sustained Release Storage Stability
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21808
专题中国科学院分子影像重点实验室
推荐引用方式
GB/T 7714
Jin Yushen,Yue Xiuli,Wu Xiaoyi,et al. Cerasomal doxorubicin with long-term storage stability and controllable sustained release[J]. Acta Biomaterialia,2012(8):3372-3380.
APA Jin Yushen,Yue Xiuli,Wu Xiaoyi,Cao Zhong,&Dai Zhifei.(2012).Cerasomal doxorubicin with long-term storage stability and controllable sustained release.Acta Biomaterialia(8),3372-3380.
MLA Jin Yushen,et al."Cerasomal doxorubicin with long-term storage stability and controllable sustained release".Acta Biomaterialia .8(2012):3372-3380.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Cerasomal doxorubici(1692KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jin Yushen]的文章
[Yue Xiuli]的文章
[Wu Xiaoyi]的文章
百度学术
百度学术中相似的文章
[Jin Yushen]的文章
[Yue Xiuli]的文章
[Wu Xiaoyi]的文章
必应学术
必应学术中相似的文章
[Jin Yushen]的文章
[Yue Xiuli]的文章
[Wu Xiaoyi]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Cerasomal doxorubicin with long-term storage stability and controllable sustained release.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。