CASIA OpenIR  > 中国科学院分子影像重点实验室
Cerasomal doxorubicin with long-term storage stability and controllable sustained release
Jin Yushen; Yue Xiuli; Wu Xiaoyi; Cao Zhong; Dai Zhifei
Source PublicationActa Biomaterialia
2012-05-30
Issue8Pages:3372-3380
AbstractLiposomal nanohybrid cerasomes display a remarkable ability to maintain their size and retain encapsulated doxorubicin (DOX) over a period of 90 days under storage conditions in solution compared with liposomes and liposils. Cerasomes retained 92.1 ± 2.9% of the drug payload after 90 days storage, much more than liposomes (35.2 ± 2.5%) and liposils (53.2 ± 5.5%). Under physiologically relevant conditions cerasomes exhibit a low initial burst in the first 5 h and subsequent sustained release of DOX over the next 150 h. Moreover, the magnitude of the initial burst and the rate of sustained release of DOX from cerasomes can be modulated by incorporating dipalmitoylphosphatidylglycerol (DPPG) in the cerasome structure and altering the ratios of the cerasome-forming lipid and phospholipids. Consequently, a wide
range of release profiles can be achieved by altering the vesicle composition. Finally, human ovarian cancer cells are effectively killed by DOX released from cerasomes. Together these results suggest that cerasomes may be a promising drug delivery system for the long-term storage and controllable sustained release of the anticancer drug DOX.

 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
KeywordCerasome Doxorubicin Controlled Release Sustained Release Storage Stability
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21808
Collection中国科学院分子影像重点实验室
Recommended Citation
GB/T 7714
Jin Yushen,Yue Xiuli,Wu Xiaoyi,et al. Cerasomal doxorubicin with long-term storage stability and controllable sustained release[J]. Acta Biomaterialia,2012(8):3372-3380.
APA Jin Yushen,Yue Xiuli,Wu Xiaoyi,Cao Zhong,&Dai Zhifei.(2012).Cerasomal doxorubicin with long-term storage stability and controllable sustained release.Acta Biomaterialia(8),3372-3380.
MLA Jin Yushen,et al."Cerasomal doxorubicin with long-term storage stability and controllable sustained release".Acta Biomaterialia .8(2012):3372-3380.
Files in This Item: Download All
File Name/Size DocType Version Access License
Cerasomal doxorubici(1692KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Jin Yushen]'s Articles
[Yue Xiuli]'s Articles
[Wu Xiaoyi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Jin Yushen]'s Articles
[Yue Xiuli]'s Articles
[Wu Xiaoyi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Jin Yushen]'s Articles
[Yue Xiuli]'s Articles
[Wu Xiaoyi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Cerasomal doxorubicin with long-term storage stability and controllable sustained release.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.