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Liposomal nanohybrid cerasomes for controlled insulin release
Jin Yushen; Li Yanyan; Pan Hongjie; Dai Zhifei
2014-09-04
发表期刊RSC Advances
期号4页码:42808–42815
摘要This study reported a facile fabrication of a reproducible and injectable cerasomal insulin formulation by encapsulating insulin into cerasomes via one-step construction. Notably, a wide range of the insulin release profiles was achieved by altering vesicle composition through incorporating the phospholipid of DPPC into cerasomes, and the mixed cerasomes showed excellent storage stability when the percentage content of DPPC was lower than 50%. It was found that the subcutaneous administration of the insulin-loaded cerasomes resulted in a reduction of blood glucose levels in a rat model of type I diabetes and the hypoglycemic effect was found to be composition dependent. The use of cerasomes significantly improved glucose tolerance from 6 hours (free insulin) to more than 16 hours (insulinloaded cerasomes). Moreover, the insulin-loaded cerasomes displayed a prolonged and stable glucoselowering profile over a period of over 12 hours compared with the insulin-loaded liposomes. These findings demonstrate that cerasomes have good potential for the use in an effective controlled release delivery system of insulin as well as other proteins with short half-life time.
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文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21811
专题中国科学院分子影像重点实验室
推荐引用方式
GB/T 7714
Jin Yushen,Li Yanyan,Pan Hongjie,et al. Liposomal nanohybrid cerasomes for controlled insulin release[J]. RSC Advances,2014(4):42808–42815.
APA Jin Yushen,Li Yanyan,Pan Hongjie,&Dai Zhifei.(2014).Liposomal nanohybrid cerasomes for controlled insulin release.RSC Advances(4),42808–42815.
MLA Jin Yushen,et al."Liposomal nanohybrid cerasomes for controlled insulin release".RSC Advances .4(2014):42808–42815.
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