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PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model
Li, Yuan1,2; Du, Yang3; Sun, Ting1,2; Xue, Huadan1,2; Jin, Zhengyu1,2; Tian, Jie3
2018-06-19
发表期刊BMC CANCER
卷号18
文章类型Article
摘要Background: Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, invasion, and adhesion of tumor cells. The aim of this study was to investigate the potential of monoclonal antibody against T cell checkpoint PD-1 in combination with chemotherapeutic drug ZA in BC mouse model.
关键词Pd-1 Zoledronic Acid Breast Cancer Therapy Checkpoint Inhibitior
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1186/s12885-018-4412-8
关键词[WOS]CHECKPOINT INHIBITORS ; PHASE-3 TRIAL ; OPEN-LABEL ; METASTASES ; ANTIBODY ; THERAPY ; LIGAND ; SAFETY
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81227901 ; Key Projects in the National Science & Technology Pillar Program(2012BAI23B06) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 81470083 ; 81527805 ; 61231004 ; 81171390)
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000435892200004
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21820
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
2.Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100730, Peoples R China
3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging CAS, 95 ZhongGuanCun East Rd, Beijing 100190, Peoples R China
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Li, Yuan,Du, Yang,Sun, Ting,et al. PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model[J]. BMC CANCER,2018,18.
APA Li, Yuan,Du, Yang,Sun, Ting,Xue, Huadan,Jin, Zhengyu,&Tian, Jie.(2018).PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.BMC CANCER,18.
MLA Li, Yuan,et al."PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model".BMC CANCER 18(2018).
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