PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model

doi:10.1186/s12885-018-4412-8

	PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model
	Li, Yuan 1,2; Du, Yang3 ; Sun, Ting 1,2; Xue, Huadan 1,2; Jin, Zhengyu 1,2; Tian, Jie3
Source Publication	BMC CANCER
	2018-06-19
Volume	18
Subtype	Article
Abstract	Background: Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, invasion, and adhesion of tumor cells. The aim of this study was to investigate the potential of monoclonal antibody against T cell checkpoint PD-1 in combination with chemotherapeutic drug ZA in BC mouse model.
Keyword	Pd-1 Zoledronic Acid Breast Cancer Therapy Checkpoint Inhibitior
WOS Headings	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1186/s12885-018-4412-8
WOS Keyword	CHECKPOINT INHIBITORS ; PHASE-3 TRIAL ; OPEN-LABEL ; METASTASES ; ANTIBODY ; THERAPY ; LIGAND ; SAFETY
Indexed By	SCI
Language	英语
Funding Organization	National Natural Science Foundation of China(81227901 ; Key Projects in the National Science & Technology Pillar Program(2012BAI23B06) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 81470083 ; 81527805 ; 61231004 ; 81171390)
WOS Research Area	Oncology
WOS Subject	Oncology
WOS ID	WOS:000435892200004
Citation statistics	Cited Times:11[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.ia.ac.cn/handle/173211/21820
Collection	中国科学院分子影像重点实验室
Affiliation	1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, 1 Shuaifuyuan, Beijing 100730, Peoples R China 2.Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100730, Peoples R China 3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging CAS, 95 ZhongGuanCun East Rd, Beijing 100190, Peoples R China
Recommended Citation GB/T 7714	Li, Yuan,Du, Yang,Sun, Ting,et al. PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model[J]. BMC CANCER,2018,18.
APA	Li, Yuan,Du, Yang,Sun, Ting,Xue, Huadan,Jin, Zhengyu,&Tian, Jie.(2018).PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.BMC CANCER,18.
MLA	Li, Yuan,et al."PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model".BMC CANCER 18(2018).

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