Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model | |
Li, Yuan1,2; Du, Yang3![]() ![]() | |
Source Publication | BMC CANCER
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2018-06-19 | |
Volume | 18 |
Subtype | Article |
Abstract | Background: Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, invasion, and adhesion of tumor cells. The aim of this study was to investigate the potential of monoclonal antibody against T cell checkpoint PD-1 in combination with chemotherapeutic drug ZA in BC mouse model. |
Keyword | Pd-1 Zoledronic Acid Breast Cancer Therapy Checkpoint Inhibitior |
WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1186/s12885-018-4412-8 |
WOS Keyword | CHECKPOINT INHIBITORS ; PHASE-3 TRIAL ; OPEN-LABEL ; METASTASES ; ANTIBODY ; THERAPY ; LIGAND ; SAFETY |
Indexed By | SCI |
Language | 英语 |
Funding Organization | National Natural Science Foundation of China(81227901 ; Key Projects in the National Science & Technology Pillar Program(2012BAI23B06) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 81470083 ; 81527805 ; 61231004 ; 81171390) |
WOS Research Area | Oncology |
WOS Subject | Oncology |
WOS ID | WOS:000435892200004 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ia.ac.cn/handle/173211/21820 |
Collection | 中国科学院分子影像重点实验室 |
Affiliation | 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, 1 Shuaifuyuan, Beijing 100730, Peoples R China 2.Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100730, Peoples R China 3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging CAS, 95 ZhongGuanCun East Rd, Beijing 100190, Peoples R China |
Recommended Citation GB/T 7714 | Li, Yuan,Du, Yang,Sun, Ting,et al. PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model[J]. BMC CANCER,2018,18. |
APA | Li, Yuan,Du, Yang,Sun, Ting,Xue, Huadan,Jin, Zhengyu,&Tian, Jie.(2018).PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.BMC CANCER,18. |
MLA | Li, Yuan,et al."PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model".BMC CANCER 18(2018). |
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