Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion | |
Sui, Jing1,2,3,4,5; Qi, Shile1,2,4; van Erp, Theo G. M.6; Bustillo, Juan7; Jiang, Rongtao1,2,4; Lin, Dongdong3; Turner, Jessica A.3,8; Damaraju, Eswar3; Mayer, Andrew R.3,7; Cui, Yue1,2; Fu, Zening3; Du, Yuhui3; Chen, Jiayu3; Potkin, Steven G.6; Preda, Adrian6; Mathalon, Daniel H.9,10; Ford, Judith M.9,10; Voyvodic, James11; Mueller, Bryon A.12; Belger, Aysenil13; McEwen, Sarah C.14; O'Leary, Daniel S.15; McMahon, Agnes16; Jiang, Tianzi1,2,4,5; Calhoun, Vince D.3,7,17 | |
发表期刊 | NATURE COMMUNICATIONS |
2018-08-02 | |
卷号 | 9期号:0页码:0 |
文章类型 | Article |
摘要 | Cognitive impairment is a feature of many psychiatric diseases, including schizophrenia. Here we aim to identify multimodal biomarkers for quantifying and predicting cognitive performance in individuals with schizophrenia and healthy controls. A supervised learning strategy is used to guide three-way multimodal magnetic resonance imaging (MRI) fusion in two independent cohorts including both healthy individuals and individuals with schizophrenia using multiple cognitive domain scores. Results highlight the salience network (gray matter, GM), corpus callosum (fractional anisotropy, FA), central executive and default-mode networks (fractional amplitude of low-frequency fluctuation, fALFF) as modality-specific biomarkers of generalized cognition. FALFF features are found to be more sensitive to cognitive domain differences, while the salience network in GM and corpus callosum in FA are highly consistent and predictive of multiple cognitive domains. These modality-specific brain regions define-in three separate cohorts-promising co-varying multimodal signatures that can be used as predictors of multi-domain cognition. |
WOS标题词 | Science & Technology |
DOI | 10.1038/s41467-018-05432-w |
关键词[WOS] | White-matter Abnormalities ; Working-memory ; 1st-episode Schizophrenia ; Brain Networks ; Functional Connectome ; Connectivity Networks ; Negative Symptoms ; Deficits ; Individuals ; Biomarkers |
收录类别 | SCI ; SSCI ; SSCI |
语种 | 英语 |
项目资助者 | Chinese National Natural Science Foundation(81471367 ; Chinese Academy of Sciences(XDB02060005) ; National High-Tech Development Plan (863 program)(2015AA020513) ; Chinese Academy of Sciences ; NIH(R01EB005846 ; NSF(1539067) ; 61773380 ; 1R01MH094524 ; 61703253) ; P20GM103472) |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000440617500004 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/21851 |
专题 | 脑网络组研究 |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Mind Res Network, Albuquerque, NM 87106 USA 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China 6.Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA 7.Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA 8.Georgia State Univ, Dept Psychol & Neurosci, Atlanta, GA 30302 USA 9.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA 10.San Francisco VA Med Ctr, San Francisco, CA 94143 USA 11.Duke Univ, Dept Radiol, Brain Imaging & Anal Ctr, Durham, NC 27710 USA 12.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA 13.Univ N Carolina, Dept Psychiat, Sch Med, Chapel Hill, NC 27599 USA 14.Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA 15.Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA 16.Univ Southern Calif, USC Stevens Neuroimaging & Informat Inst, San Diego, CA 90033 USA 17.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA |
第一作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Sui, Jing,Qi, Shile,van Erp, Theo G. M.,et al. Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion[J]. NATURE COMMUNICATIONS,2018,9(0):0. |
APA | Sui, Jing.,Qi, Shile.,van Erp, Theo G. M..,Bustillo, Juan.,Jiang, Rongtao.,...&Calhoun, Vince D..(2018).Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion.NATURE COMMUNICATIONS,9(0),0. |
MLA | Sui, Jing,et al."Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion".NATURE COMMUNICATIONS 9.0(2018):0. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论