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Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion
Sui, Jing1,2,3,4,5; Qi, Shile1,2,4; van Erp, Theo G. M.6; Bustillo, Juan7; Jiang, Rongtao1,2,4; Lin, Dongdong3; Turner, Jessica A.3,8; Damaraju, Eswar3; Mayer, Andrew R.3,7; Cui, Yue1,2; Fu, Zening3; Du, Yuhui3; Chen, Jiayu3; Potkin, Steven G.6; Preda, Adrian6; Mathalon, Daniel H.9,10; Ford, Judith M.9,10; Voyvodic, James11; Mueller, Bryon A.12; Belger, Aysenil13; McEwen, Sarah C.14; O'Leary, Daniel S.15; McMahon, Agnes16; Jiang, Tianzi1,2,4,5; Calhoun, Vince D.3,7,17

Cognitive impairment is a feature of many psychiatric diseases, including schizophrenia. Here we aim to identify multimodal biomarkers for quantifying and predicting cognitive performance in individuals with schizophrenia and healthy controls. A supervised learning strategy is used to guide three-way multimodal magnetic resonance imaging (MRI) fusion in two independent cohorts including both healthy individuals and individuals with schizophrenia using multiple cognitive domain scores. Results highlight the salience network (gray matter, GM), corpus callosum (fractional anisotropy, FA), central executive and default-mode networks (fractional amplitude of low-frequency fluctuation, fALFF) as modality-specific biomarkers of generalized cognition. FALFF features are found to be more sensitive to cognitive domain differences, while the salience network in GM and corpus callosum in FA are highly consistent and predictive of multiple cognitive domains. These modality-specific brain regions define-in three separate cohorts-promising co-varying multimodal signatures that can be used as predictors of multi-domain cognition.

WOS HeadingsScience & Technology
WOS KeywordWhite-matter Abnormalities ; Working-memory ; 1st-episode Schizophrenia ; Brain Networks ; Functional Connectome ; Connectivity Networks ; Negative Symptoms ; Deficits ; Individuals ; Biomarkers
Indexed BySCI ; SSCI ; SSCI
Funding OrganizationChinese National Natural Science Foundation(81471367 ; Chinese Academy of Sciences(XDB02060005) ; National High-Tech Development Plan (863 program)(2015AA020513) ; Chinese Academy of Sciences ; NIH(R01EB005846 ; NSF(1539067) ; 61773380 ; 1R01MH094524 ; 61703253) ; P20GM103472)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000440617500004
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Mind Res Network, Albuquerque, NM 87106 USA
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
6.Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA
7.Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA
8.Georgia State Univ, Dept Psychol & Neurosci, Atlanta, GA 30302 USA
9.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
10.San Francisco VA Med Ctr, San Francisco, CA 94143 USA
11.Duke Univ, Dept Radiol, Brain Imaging & Anal Ctr, Durham, NC 27710 USA
12.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
13.Univ N Carolina, Dept Psychiat, Sch Med, Chapel Hill, NC 27599 USA
14.Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
15.Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA
16.Univ Southern Calif, USC Stevens Neuroimaging & Informat Inst, San Diego, CA 90033 USA
17.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Sui, Jing,Qi, Shile,van Erp, Theo G. M.,et al. Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion[J]. NATURE COMMUNICATIONS,2018,9(0):0.
APA Sui, Jing.,Qi, Shile.,van Erp, Theo G. M..,Bustillo, Juan.,Jiang, Rongtao.,...&Calhoun, Vince D..(2018).Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion.NATURE COMMUNICATIONS,9(0),0.
MLA Sui, Jing,et al."Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion".NATURE COMMUNICATIONS 9.0(2018):0.
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