CASIA OpenIR  > 中国科学院分子影像重点实验室
A gel system for single instillation of non-muscle-invasive bladder Cancer: A "divide-and-rule" strategy
Guo, Pengyu1,2,3,4; Shang, Wenting1,2,3,4; Peng, Li1,2,3,4; Wang, Lu1,4; Wang, Hongzhi1,4; Han, Ziyu2,3; Jiang, Hongmei2,3; Tian, Jie2,3; Wang, Kun2,3; Xu, Wanhai1,4
Source PublicationJOURNAL OF CONTROLLED RELEASE
2018-09-10
Volume285Pages:46-55
SubtypeArticle
AbstractSingle instillation (SI) reduces recurrence of non-muscle-invasive bladder cancer by chemoresecting floating tumor cells and residual tumor lesions (RTLs) after transurethral resection of the bladder, but with limited efficacy. Current studies improved this by prolonging retention time and increasing penetration to bladder wall, ignoring that the two separate factors should be treated in different ways. Here, we introduced a smart gel system-based SI to prevent re-implantation of tumor cells (RTCs) and ablate RTLs in a "divide-and-rule" approach. The gel system was synthesized by PEG-PAMAM and dextran aldehyde and composed of gold nanorods and gemcitabine for photothermal therapy and chemotherapy, respectively. It was developed to provide dextran aldehyde-selective adhesion with tissue amines. Since tumor surface expressed high levels of collagen, the exposed amines could act as adhesion points for the gel system. Thus, the gel presented more affinity to tumor tissues. When being instilled, it could form a protective layer on the inner face of the entire bladder wall immediately, preventing RTCs in early time. And it persisted long at the tumor site, ablating RTLs. Our data proved the gel system improved intravesical treatment efficacy in a "divide-and-rule" approach and might be a promising treatment strategy for SI.
KeywordBladder Cancer Single Instillation Gel Mouse Model
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI10.1016/j.jconrel.2018.06.036
WOS KeywordINTRAVESICAL DRUG-DELIVERY ; SELECTIVE CYTOTOXICITY ; THERAPY ; GEMCITABINE ; DIAGNOSIS ; NANOPARTICLES ; IMPLANTATION ; CHEMOTHERAPY ; INHIBITION ; CARCINOMA
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81771898 ; National Key R&D Program of China(2017YFA0205200) ; 81227901 ; 61231004 ; 81501540 ; 61671449 ; 61501462)
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000441737400005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21858
Collection中国科学院分子影像重点实验室
Affiliation1.Harbin Med Univ, Hosp 4, Urol Surg Dept, Harbin 150001, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
4.Heilongjiang Key Lab Sci Res Urol, Harbin 150001, Heilongjiang, Peoples R China
Recommended Citation
GB/T 7714
Guo, Pengyu,Shang, Wenting,Peng, Li,et al. A gel system for single instillation of non-muscle-invasive bladder Cancer: A "divide-and-rule" strategy[J]. JOURNAL OF CONTROLLED RELEASE,2018,285:46-55.
APA Guo, Pengyu.,Shang, Wenting.,Peng, Li.,Wang, Lu.,Wang, Hongzhi.,...&Xu, Wanhai.(2018).A gel system for single instillation of non-muscle-invasive bladder Cancer: A "divide-and-rule" strategy.JOURNAL OF CONTROLLED RELEASE,285,46-55.
MLA Guo, Pengyu,et al."A gel system for single instillation of non-muscle-invasive bladder Cancer: A "divide-and-rule" strategy".JOURNAL OF CONTROLLED RELEASE 285(2018):46-55.
Files in This Item: Download All
File Name/Size DocType Version Access License
4.Pengyu Guo.pdf(3556KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo, Pengyu]'s Articles
[Shang, Wenting]'s Articles
[Peng, Li]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo, Pengyu]'s Articles
[Shang, Wenting]'s Articles
[Peng, Li]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo, Pengyu]'s Articles
[Shang, Wenting]'s Articles
[Peng, Li]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 4.Pengyu Guo.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.