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A gel system for single instillation of non-muscle-invasive bladder Cancer: A "divide-and-rule" strategy
Guo, Pengyu1,2,3,4; Shang, Wenting1,2,3,4; Peng, Li1,2,3,4; Wang, Lu1,4; Wang, Hongzhi1,4; Han, Ziyu2,3; Jiang, Hongmei2,3; Tian, Jie2,3; Wang, Kun2,3; Xu, Wanhai1,4
AbstractSingle instillation (SI) reduces recurrence of non-muscle-invasive bladder cancer by chemoresecting floating tumor cells and residual tumor lesions (RTLs) after transurethral resection of the bladder, but with limited efficacy. Current studies improved this by prolonging retention time and increasing penetration to bladder wall, ignoring that the two separate factors should be treated in different ways. Here, we introduced a smart gel system-based SI to prevent re-implantation of tumor cells (RTCs) and ablate RTLs in a "divide-and-rule" approach. The gel system was synthesized by PEG-PAMAM and dextran aldehyde and composed of gold nanorods and gemcitabine for photothermal therapy and chemotherapy, respectively. It was developed to provide dextran aldehyde-selective adhesion with tissue amines. Since tumor surface expressed high levels of collagen, the exposed amines could act as adhesion points for the gel system. Thus, the gel presented more affinity to tumor tissues. When being instilled, it could form a protective layer on the inner face of the entire bladder wall immediately, preventing RTCs in early time. And it persisted long at the tumor site, ablating RTLs. Our data proved the gel system improved intravesical treatment efficacy in a "divide-and-rule" approach and might be a promising treatment strategy for SI.
KeywordBladder Cancer Single Instillation Gel Mouse Model
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(81771898 ; National Key R&D Program of China(2017YFA0205200) ; 81227901 ; 61231004 ; 81501540 ; 61671449 ; 61501462)
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000441737400005
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Harbin Med Univ, Hosp 4, Urol Surg Dept, Harbin 150001, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
4.Heilongjiang Key Lab Sci Res Urol, Harbin 150001, Heilongjiang, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Guo, Pengyu,Shang, Wenting,Peng, Li,et al. A gel system for single instillation of non-muscle-invasive bladder Cancer: A "divide-and-rule" strategy[J]. JOURNAL OF CONTROLLED RELEASE,2018,285:46-55.
APA Guo, Pengyu.,Shang, Wenting.,Peng, Li.,Wang, Lu.,Wang, Hongzhi.,...&Xu, Wanhai.(2018).A gel system for single instillation of non-muscle-invasive bladder Cancer: A "divide-and-rule" strategy.JOURNAL OF CONTROLLED RELEASE,285,46-55.
MLA Guo, Pengyu,et al."A gel system for single instillation of non-muscle-invasive bladder Cancer: A "divide-and-rule" strategy".JOURNAL OF CONTROLLED RELEASE 285(2018):46-55.
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