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Core networks and their reconfiguration patterns across cognitive loads
Zuo, Nianming1,2,6; Yang, Zhengyi1,2; Liu, Yong1,2,3,6; Li, Jin1,2; Jiang, Tianzi1,2,3,4,5,6
Source PublicationHUMAN BRAIN MAPPING
2018-09-01
Volume39Issue:9Pages:3546-3557
SubtypeArticle
AbstractDifferent cognitively demanding tasks recruit globally distributed but functionally specific networks. However, the configuration of core networks and their reconfiguration patterns across cognitive loads remain unclear, as does whether these patterns are indicators for the performance of cognitive tasks. In this study, we analyzed functional magnetic resonance imaging data of a large cohort of 448 subjects, acquired with the brain at resting state and executing N-back working memory (WM) tasks. We discriminated core networks by functional interaction strength and connection flexibility. Results demonstrated that the frontoparietal network (FPN) and default mode network (DMN) were core networks, but each exhibited different patterns across cognitive loads. The FPN and DMN both showed strengthened internal connections at the low demand state (0-back) compared with the resting state (control level); whereas, from the low (0-back) to high demand state (2-back), some connections to the FPN weakened and were rewired to the DMN (whose connections all remained strong). Of note, more intensive reconfiguration of both the whole brain and core networks (but no other networks) across load levels indicated relatively poor cognitive performance. Collectively these findings indicate that the FPN and DMN have distinct roles and reconfiguration patterns across cognitively demanding loads. This study advances our understanding of the core networks and their reconfiguration patterns across cognitive loads and provides a new feature to evaluate and predict cognitive capability (e.g., WM performance) based on brain networks.
KeywordBrain Network Functional Connectivity Functional Mri Network Reconfiguration Working Memory
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.24193
WOS KeywordDEFAULT-MODE NETWORK ; RESTING-STATE FMRI ; HUMAN CONNECTOME PROJECT ; WORKING-MEMORY ; BRAIN NETWORKS ; FUNCTIONAL CONNECTIVITY ; COMMUNITY STRUCTURE ; GLOBAL SIGNAL ; DYNAMIC RECONFIGURATION ; FRONTOPARIETAL CONTROL
Indexed BySCI ; SSCI
Language英语
Funding OrganizationMajor Research plan of the National Natural Science Foundation of China(91432302) ; International Cooperation and Exchange of the National Natural Science Foundation of China(31620103905) ; Special Projects of Brain Science of Beijing Municipal Science & Technology Commission(Z161100000216139) ; Human Connectome Project, WU-Minn Consortium(1U54MH091657) ; McDonnell Center for Systems Neuroscience at Washington University
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000441276600006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21868
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab Neuroinformat, Minist Educ, Chengdu 625014, Sichuan, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zuo, Nianming,Yang, Zhengyi,Liu, Yong,et al. Core networks and their reconfiguration patterns across cognitive loads[J]. HUMAN BRAIN MAPPING,2018,39(9):3546-3557.
APA Zuo, Nianming,Yang, Zhengyi,Liu, Yong,Li, Jin,&Jiang, Tianzi.(2018).Core networks and their reconfiguration patterns across cognitive loads.HUMAN BRAIN MAPPING,39(9),3546-3557.
MLA Zuo, Nianming,et al."Core networks and their reconfiguration patterns across cognitive loads".HUMAN BRAIN MAPPING 39.9(2018):3546-3557.
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