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Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging
Zhan, Yonghua1; Shi, Sixiang2; Ehlerding, Emily B.3; Graves, Stephen A.3; Goel, Shreya2; Engle, Jonathan W.3; Liang, Jimin1; Tian, Jie5; Cai, Weibo2,3,4
2017-11-08
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号9期号:44页码:38304-38312
文章类型Article
摘要Manganese oxide nanoparticles (Mn3O4 NPs) have attracted a great deal of attention in the field of biomedical imaging because of their ability to create an enhanced imaging signal in MRI as novel potent T-1 contrast agents. In this study, we present tumor vasculature-targeted imaging in mice using Mn3O4 NPs through conjugation to the anti-CD105 antibody TRC105 and radionuclide copper-64 (Cu-64, t(1/2): 12.7 h). The Mn3O4 conjugated NPs, Cu-64-NOTAMn(3)O(4)@PEG-TRC105, exhibited sufficient stability in vitro and in vivo. Serial positron emission tomography (PET) and magnetic resonance imaging (MRI) studies evaluated the pharmacokinetics and demonstrated targeting of Cu-64-NOTA-Mn3O4@PEG-TRC105 to 4T(1) murine breast tumors in vivo, compared to Cu-64-NOTA-Mn3O4@PEG. The specificity of Cu-64-NOTA-Mn3O4@PEG-TRC105 for the vascular marker CD105 was confirmed through in vivo, in vitro, and ex vivo experiments. Since Mn3O4 conjugated NPs exhibited desirable properties for T1 enhanced imaging and low toxicity, the tumor-specific Mn3O4 conjugated NPs reported in this study may serve as promising multifunctional nanoplatforms for precise cancer imaging and diagnosis.
关键词Manganese Oxide Nanoparticles Cancer Positron Emission Tomography (Pet) Magnetic Resonance Imaging (Mri) Cd105 (Endoglin)
WOS标题词Science & Technology ; Technology
DOI10.1021/acsami.7b12216
关键词[WOS]IN-VIVO ; LOW-TEMPERATURE ; DRUG-DELIVERY ; MN3O4 NANOPARTICLES ; MONOCLONAL-ANTIBODY ; MNO NANOPARTICLES ; ENDOGLIN ANTIBODY ; CONTRAST AGENTS ; MRI CONTRAST ; CANCER
收录类别SCI
语种英语
项目资助者University of Wisconsin Madison ; National Institutes of Health(NIBIB/NCI 1R01CA169365 ; American Cancer Society(125246-RSG-13-099-01-CCE) ; National Natural Science Foundation of China(81227901 ; Natural Science Basic Research Plan in Shaanxi Province of China(2017JM8057) ; Fundamental Research Funds for the Central Universities(JB171204) ; 1R01CA205101 ; 11727813 ; 1R01EB021336 ; 81571725 ; T32GM008505 ; 81230033 ; T32CA009206 ; 31371006 ; P30CA014520) ; 61405149 ; 81660505 ; 81627807)
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000415140800017
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21920
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
2.Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA
3.Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA
4.Univ Wisconsin, Carbone Canc Ctr, Madison, WI 53705 USA
5.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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Zhan, Yonghua,Shi, Sixiang,Ehlerding, Emily B.,et al. Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(44):38304-38312.
APA Zhan, Yonghua.,Shi, Sixiang.,Ehlerding, Emily B..,Graves, Stephen A..,Goel, Shreya.,...&Cai, Weibo.(2017).Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,9(44),38304-38312.
MLA Zhan, Yonghua,et al."Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 9.44(2017):38304-38312.
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