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White Matter Microstructural Properties are Related to Inter-Individual Differences in Cognitive Instability after Sleep Deprivation
Zhu, Yuanqiang1,2; Wang, Liuxian2; Xi, Yibin2; Dai, Tian1; Fei, Ningbo1; Liu, Lin1; Xu, Ziliang1; Yang, Xuejuan1; Fu, Chang3; Sun, Jinbo1; Xu, Junling3; Shi, Dapeng3; Tian, Jie1,4; Yin, Hong2; Qin, Wei1,5
2017-12-04
发表期刊NEUROSCIENCE
卷号365页码:206-216
文章类型Article
摘要Several diseases are characterized by cognitive instability, which is amplified in the conditions of sleep deprivation (SD). Cognitive instability in SD can be examined by the number of lapses on the psychomotor vigilance test (PVT), which is considered to be a gold standard in the field. However, the number of PVT lapses widely range according to inter-individual differences, from apparent cognitive resistance to severe cognitive impairment. In this study, tract-based spatial statistical analyses with multiple diffusion tensor imaging-derived characteristics (i.e., fractional anisotropy (FA), mean diffusivity, radial diffusivity, and axial diffusivity) were employed to investigate the relationships between the number of PVT lapses and the diffusion characteristics. A hierarchical linear regression model was then used to assess the contributions of tract-specific FA values in predicting PVT lapses. Finally, dichotomized analysis was used to investigate white matter (WM) differences between resilient and vulnerable groups. Our results showed significant negative correlations between numbers of PVT lapses and FA in multiple WM tracts, with the FA variations in the superior longitudinal fasciculus and splenium of the corpus callosum accounting for nearly 37.5% of individual variability in PVT lapses. In addition, dichotomized analyses indicated that the resilient participants exhibited significantly higher FA values compared with the vulnerable participants. Together, these findings suggest that cognitive instability after SD was closely associated with individual differences in WM integrity. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
关键词Sleep Deprivation Cognitive Instability Individual Difference Diffusion Tensor Imaging Psychomotor Vigilance Test
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neuroscience.2017.09.047
关键词[WOS]INDIVIDUAL-DIFFERENCES ; FUNCTIONAL CONNECTIVITY ; SUSTAINED ATTENTION ; HUMAN BRAIN ; VULNERABILITY ; PERFORMANCE ; VARIABILITY ; MEMORY ; ACTIVATION ; INTEGRITY
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000415966200017
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21921
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Sleep & Neuroimage Grp, Xian 710071, Shaanxi, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian 710032, Shaanxi, Peoples R China
3.Zhengzhou Univ, Peoples Hosp, Dept Nucl Med, Zhengzhou, Henan, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
5.266 Xinglong Sect Xifeng Rd, Xian 710126, Shaanxi, Peoples R China
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Zhu, Yuanqiang,Wang, Liuxian,Xi, Yibin,et al. White Matter Microstructural Properties are Related to Inter-Individual Differences in Cognitive Instability after Sleep Deprivation[J]. NEUROSCIENCE,2017,365:206-216.
APA Zhu, Yuanqiang.,Wang, Liuxian.,Xi, Yibin.,Dai, Tian.,Fei, Ningbo.,...&Qin, Wei.(2017).White Matter Microstructural Properties are Related to Inter-Individual Differences in Cognitive Instability after Sleep Deprivation.NEUROSCIENCE,365,206-216.
MLA Zhu, Yuanqiang,et al."White Matter Microstructural Properties are Related to Inter-Individual Differences in Cognitive Instability after Sleep Deprivation".NEUROSCIENCE 365(2017):206-216.
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