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No differences in brain microstructure between young KIBRA-C carriers and non-carriers
Hu, Li1; Xu, Qunxing2; Li, Jizhen3; Wang, Feifei1; Xu, Xinghua1; Sun, Zhiyuan1; Ma, Xiangxing1; Liu, Yong4; Wang, Qing1; Wang, Dawei1
2018-01-02
发表期刊ONCOTARGET
卷号9期号:1页码:1200-1209
文章类型Article
摘要KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. We recruited 100 healthy young volunteers, including 53 TT carriers and 47 C allele carriers. No differences were detected between the TT homozygotes and C-allele carriers for any diffusion and kurtosis parameter. These results indicate KIBRA rs17070145 polymorphism likely has little or no effect on brain microstructure in young adults.
关键词Dki Kibra Brain Microstructure Young
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.18632/oncotarget.23348
关键词[WOS]MILD COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE ; DIFFUSION KURTOSIS ; EPISODIC MEMORY ; APOE EPSILON-4 ; HEALTHY ADOLESCENTS ; GENE VARIANTS ; POLYMORPHISM ; ASSOCIATION ; PERFORMANCE
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81400890 ; Shandong Provincial Key Research and Development Program(2017GSF218093 ; Shandong Provincial Science and Technology Major Project(2015ZDXX0801A01) ; Fundamental Research Funds of Shandong University(2017JC013) ; 81571062) ; 2017CXGC1502 ; 2017CXGC1504)
WOS研究方向Oncology ; Cell Biology
WOS类目Oncology ; Cell Biology
WOS记录号WOS:000419615500097
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21936
专题脑网络组研究中心
作者单位1.Shandong Univ, Qilu Hosp, Dept Radiol, Jinan 250012, Shandong, Peoples R China
2.Shandong Univ, Qilu Hosp, Med Examinat Ctr, Jinan 250012, Shandong, Peoples R China
3.Mental Hlth Ctr Shandong Prov, Jinan 250012, Shandong, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
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Hu, Li,Xu, Qunxing,Li, Jizhen,et al. No differences in brain microstructure between young KIBRA-C carriers and non-carriers[J]. ONCOTARGET,2018,9(1):1200-1209.
APA Hu, Li.,Xu, Qunxing.,Li, Jizhen.,Wang, Feifei.,Xu, Xinghua.,...&Wang, Dawei.(2018).No differences in brain microstructure between young KIBRA-C carriers and non-carriers.ONCOTARGET,9(1),1200-1209.
MLA Hu, Li,et al."No differences in brain microstructure between young KIBRA-C carriers and non-carriers".ONCOTARGET 9.1(2018):1200-1209.
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