CASIA OpenIR  > 脑网络组研究中心
No differences in brain microstructure between young KIBRA-C carriers and non-carriers
Hu, Li1; Xu, Qunxing2; Li, Jizhen3; Wang, Feifei1; Xu, Xinghua1; Sun, Zhiyuan1; Ma, Xiangxing1; Liu, Yong4; Wang, Qing1; Wang, Dawei1
Source PublicationONCOTARGET
2018-01-02
Volume9Issue:1Pages:1200-1209
SubtypeArticle
AbstractKIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. We recruited 100 healthy young volunteers, including 53 TT carriers and 47 C allele carriers. No differences were detected between the TT homozygotes and C-allele carriers for any diffusion and kurtosis parameter. These results indicate KIBRA rs17070145 polymorphism likely has little or no effect on brain microstructure in young adults.
KeywordDki Kibra Brain Microstructure Young
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.18632/oncotarget.23348
WOS KeywordMILD COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE ; DIFFUSION KURTOSIS ; EPISODIC MEMORY ; APOE EPSILON-4 ; HEALTHY ADOLESCENTS ; GENE VARIANTS ; POLYMORPHISM ; ASSOCIATION ; PERFORMANCE
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81400890 ; Shandong Provincial Key Research and Development Program(2017GSF218093 ; Shandong Provincial Science and Technology Major Project(2015ZDXX0801A01) ; Fundamental Research Funds of Shandong University(2017JC013) ; 81571062) ; 2017CXGC1502 ; 2017CXGC1504)
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000419615500097
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21936
Collection脑网络组研究中心
Affiliation1.Shandong Univ, Qilu Hosp, Dept Radiol, Jinan 250012, Shandong, Peoples R China
2.Shandong Univ, Qilu Hosp, Med Examinat Ctr, Jinan 250012, Shandong, Peoples R China
3.Mental Hlth Ctr Shandong Prov, Jinan 250012, Shandong, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Hu, Li,Xu, Qunxing,Li, Jizhen,et al. No differences in brain microstructure between young KIBRA-C carriers and non-carriers[J]. ONCOTARGET,2018,9(1):1200-1209.
APA Hu, Li.,Xu, Qunxing.,Li, Jizhen.,Wang, Feifei.,Xu, Xinghua.,...&Wang, Dawei.(2018).No differences in brain microstructure between young KIBRA-C carriers and non-carriers.ONCOTARGET,9(1),1200-1209.
MLA Hu, Li,et al."No differences in brain microstructure between young KIBRA-C carriers and non-carriers".ONCOTARGET 9.1(2018):1200-1209.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu, Li]'s Articles
[Xu, Qunxing]'s Articles
[Li, Jizhen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu, Li]'s Articles
[Xu, Qunxing]'s Articles
[Li, Jizhen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu, Li]'s Articles
[Xu, Qunxing]'s Articles
[Li, Jizhen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.