No differences in brain microstructure between young KIBRA-C carriers and non-carriers

doi:10.18632/oncotarget.23348

	No differences in brain microstructure between young KIBRA-C carriers and non-carriers
	Hu, Li 1; Xu, Qunxing 2; Li, Jizhen 3; Wang, Feifei 1; Xu, Xinghua 1; Sun, Zhiyuan 1; Ma, Xiangxing 1; Liu, Yong4 ; Wang, Qing 1; Wang, Dawei 1
发表期刊	ONCOTARGET
	2018-01-02
卷号	9 期号:1 页码:1200-1209
文章类型	Article
摘要	KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. We recruited 100 healthy young volunteers, including 53 TT carriers and 47 C allele carriers. No differences were detected between the TT homozygotes and C-allele carriers for any diffusion and kurtosis parameter. These results indicate KIBRA rs17070145 polymorphism likely has little or no effect on brain microstructure in young adults.
关键词	Dki Kibra Brain Microstructure Young
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.18632/oncotarget.23348
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE ; DIFFUSION KURTOSIS ; EPISODIC MEMORY ; APOE EPSILON-4 ; HEALTHY ADOLESCENTS ; GENE VARIANTS ; POLYMORPHISM ; ASSOCIATION ; PERFORMANCE
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81400890 ; Shandong Provincial Key Research and Development Program(2017GSF218093 ; Shandong Provincial Science and Technology Major Project(2015ZDXX0801A01) ; Fundamental Research Funds of Shandong University(2017JC013) ; 81571062) ; 2017CXGC1502 ; 2017CXGC1504)
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000419615500097
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/21936
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Shandong Univ, Qilu Hosp, Dept Radiol, Jinan 250012, Shandong, Peoples R China 2.Shandong Univ, Qilu Hosp, Med Examinat Ctr, Jinan 250012, Shandong, Peoples R China 3.Mental Hlth Ctr Shandong Prov, Jinan 250012, Shandong, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Hu, Li,Xu, Qunxing,Li, Jizhen,et al. No differences in brain microstructure between young KIBRA-C carriers and non-carriers[J]. ONCOTARGET,2018,9(1):1200-1209.
APA	Hu, Li.,Xu, Qunxing.,Li, Jizhen.,Wang, Feifei.,Xu, Xinghua.,...&Wang, Dawei.(2018).No differences in brain microstructure between young KIBRA-C carriers and non-carriers.ONCOTARGET,9(1),1200-1209.
MLA	Hu, Li,et al."No differences in brain microstructure between young KIBRA-C carriers and non-carriers".ONCOTARGET 9.1(2018):1200-1209.